Review
doi: 10.1002/ajh.25374.
Epub 2019 Jan 8.
Neutropenia in the age of genetic testing: Advances and challenges
Affiliations
- PMID: 30536760
- PMCID: PMC6380907
- DOI: 10.1002/ajh.25374
Item in Clipboard
Review
Neutropenia in the age of genetic testing: Advances and challenges
Am J Hematol.
2019 Mar.
Abstract
Identification of genetic causes of neutropenia informs precision medicine approaches to medical management and treatment. Accurate diagnosis of genetic neutropenia disorders informs treatment options, enables risk stratification, cancer surveillance, and attention to associated medical complications. The rapidly expanding genetic testing options for the evaluation of neutropenia have led to exciting advances but also new challenges. This review provides a practical guide to germline genetic testing for neutropenia.
© 2018 Wiley Periodicals, Inc.
Similar articles
-
Molecular diagnosis and monitoring of leukemia and lymphoma.Leuk Res. 1993 Dec;17(12):1073-8. doi: 10.1016/0145-2126(93)90166-i. Leuk Res. 1993. PMID: 8246612 No abstract available.
-
Genetic Predisposition to Myelodysplastic Syndrome in Clinical Practice.Hematol Oncol Clin North Am. 2020 Apr;34(2):333-356. doi: 10.1016/j.hoc.2019.10.002. Epub 2020 Jan 6. Hematol Oncol Clin North Am. 2020. PMID: 32089214 Free PMC article. Review.
-
Proposal for the clinical detection and management of patients and their family members with familial myelodysplastic syndrome/acute leukemia predisposition syndromes.Leuk Lymphoma. 2013 Jan;54(1):28-35. doi: 10.3109/10428194.2012.701738. Epub 2012 Jul 9. Leuk Lymphoma. 2013. PMID: 22691122 Review.
-
Genetic predisposition to MDS: diagnosis and management.Hematology Am Soc Hematol Educ Program. 2019 Dec 6;2019(1):110-119. doi: 10.1182/hematology.2019000021. Hematology Am Soc Hematol Educ Program. 2019. PMID: 31808839 Free PMC article.
-
[Leukemias and malignant lymphomas in children].Ugeskr Laeger. 1999 Apr 12;161(15):2191-5. Ugeskr Laeger. 1999. PMID: 10222813 Review. Danish. No abstract available.
Cited by
-
Outcomes for patients with severe chronic neutropenia treated with granulocyte colony-stimulating factor.Blood Adv. 2022 Jul 12;6(13):3861-3869. doi: 10.1182/bloodadvances.2021005684. Blood Adv. 2022. PMID: 35476051 Free PMC article.
-
Isolated Severe Neutropenia in Adults, Evaluation of Underlying Causes and Outcomes, Real-World Data Collected over a 5-Year Period in a Tertiary Referral Hospital.Medicina (Kaunas). 2024 Sep 26;60(10):1576. doi: 10.3390/medicina60101576. Medicina (Kaunas). 2024. PMID: 39459363 Free PMC article.
-
Impaired myelopoiesis in congenital neutropenia: insights into clonal and malignant hematopoiesis.Hematology Am Soc Hematol Educ Program. 2021 Dec 10;2021(1):514-520. doi: 10.1182/hematology.2021000286. Hematology Am Soc Hematol Educ Program. 2021. PMID: 34889405 Free PMC article.
-
Diagnosis and therapeutic decision-making for the neutropenic patient.Hematology Am Soc Hematol Educ Program. 2021 Dec 10;2021(1):492-503. doi: 10.1182/hematology.2021000284. Hematology Am Soc Hematol Educ Program. 2021. PMID: 34889413 Free PMC article.
-
Gene Therapy to the Retina and the Cochlea.Front Neurosci. 2021 Mar 17;15:652215. doi: 10.3389/fnins.2021.652215. eCollection 2021. Front Neurosci. 2021. PMID: 33815052 Free PMC article. Review.
References
-
- Carlsson G, Fasth A, Berglof E, et al. Incidence of severe congenital neutropenia in Sweden and risk of evolution to myelodysplastic syndrome/leukaemia. Br J Haematol 2012;158:363–9. 5. - PubMed
-
- Donadieu J, Beaupain B, Mahlaoui N, Bellanne-Chantelot C. Epidemiology of congenital neutropenia. Hematology/oncology clinics of North America. 2013;27(1):1–17, vii. - PubMed
-
- Donadieu J, Beaupain B, Fenneteau O, Bellanne-Chantelot C. Congenital neutropenia in the era of genomics: classification, diagnosis, and natural history. Br J Haematol 2017;179:557–74. - PubMed
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Medical