Vaccination in the elderly: The challenge of immune changes with aging

doi:10.1016/j.smim.2018.10.010

Review

. 2018 Dec:40:83-94.

doi: 10.1016/j.smim.2018.10.010.

Vaccination in the elderly: The challenge of immune changes with aging

Annalisa Ciabattini¹, Christine Nardini², Francesco Santoro¹, Paolo Garagnani³, Claudio Franceschi⁴, Donata Medaglini⁵

Affiliations

¹ Laboratory of Molecular Microbiology and Biotechnology, Department of Medical Biotechnologies, University of Siena, Viale Bracci 16, 53100, Siena, Italy.
² Clinical Chemistry, Department of Laboratory Medicine, Karolinska Institutet at Huddinge University Hospital, SE-171 77, Stockholm, Sweden; Personal Genomics S.r.l., Via Roveggia, 43B, 37134, Verona, Italy; CNR IAC "Mauro Picone", Via dei Taurini, 19, 00185, Roma, Italy.
³ Clinical Chemistry, Department of Laboratory Medicine, Karolinska Institutet at Huddinge University Hospital, SE-171 77, Stockholm, Sweden; Interdepartmental Centre 'L. Galvani' (CIG), University of Bologna, Via G. Petroni 26, 40139, Bologna, Italy; Department of Experimental, Diagnostic and Specialty Medicine (DIMES) - University of Bologna,40139, Bologna, Italy.
⁴ IRCCS, Institute of Neurological Sciences of Bologna, Via Altura 3, 40139, Bologna, Italy. Electronic address: claudio.franceschi@unibo.it.
⁵ Laboratory of Molecular Microbiology and Biotechnology, Department of Medical Biotechnologies, University of Siena, Viale Bracci 16, 53100, Siena, Italy. Electronic address: donata.medaglini@unisi.it.

PMID: 30501873
DOI: 10.1016/j.smim.2018.10.010

Free article

Review

Vaccination in the elderly: The challenge of immune changes with aging

Annalisa Ciabattini et al. Semin Immunol. 2018 Dec.

Free article

. 2018 Dec:40:83-94.

doi: 10.1016/j.smim.2018.10.010.

Authors

Annalisa Ciabattini¹, Christine Nardini², Francesco Santoro¹, Paolo Garagnani³, Claudio Franceschi⁴, Donata Medaglini⁵

Affiliations

¹ Laboratory of Molecular Microbiology and Biotechnology, Department of Medical Biotechnologies, University of Siena, Viale Bracci 16, 53100, Siena, Italy.
² Clinical Chemistry, Department of Laboratory Medicine, Karolinska Institutet at Huddinge University Hospital, SE-171 77, Stockholm, Sweden; Personal Genomics S.r.l., Via Roveggia, 43B, 37134, Verona, Italy; CNR IAC "Mauro Picone", Via dei Taurini, 19, 00185, Roma, Italy.
³ Clinical Chemistry, Department of Laboratory Medicine, Karolinska Institutet at Huddinge University Hospital, SE-171 77, Stockholm, Sweden; Interdepartmental Centre 'L. Galvani' (CIG), University of Bologna, Via G. Petroni 26, 40139, Bologna, Italy; Department of Experimental, Diagnostic and Specialty Medicine (DIMES) - University of Bologna,40139, Bologna, Italy.
⁴ IRCCS, Institute of Neurological Sciences of Bologna, Via Altura 3, 40139, Bologna, Italy. Electronic address: claudio.franceschi@unibo.it.
⁵ Laboratory of Molecular Microbiology and Biotechnology, Department of Medical Biotechnologies, University of Siena, Viale Bracci 16, 53100, Siena, Italy. Electronic address: donata.medaglini@unisi.it.

PMID: 30501873
DOI: 10.1016/j.smim.2018.10.010

Abstract

The unprecedented increase of life expectancy challenges society to protect the elderly from morbidity and mortality making vaccination a crucial mean to safeguard this population. Indeed, infectious diseases, such as influenza and pneumonia, are among the top killers of elderly people in the world. Elderly individuals are more prone to severe infections and less responsive to vaccination prevention, due to immunosenescence combined with the progressive increase of a proinflammatory status characteristic of the aging process (inflammaging). These factors are responsible for most age-related diseases and correlate with poor response to vaccination. Therefore, it is of utmost interest to deepen the knowledge regarding the role of inflammaging in vaccination responsiveness to support the development of effective vaccination strategies designed for elderly. In this review we analyse the impact of age-associated factors such as inflammaging, immunosenescence and immunobiography on immune response to vaccination in the elderly, and we consider systems biology approaches as a mean for integrating a multitude of data in order to rationally design vaccination approaches specifically tailored for the elderly.

Keywords: Elderly vaccination; Immunobiography; Immunosenescence; Inflammaging; Systems biology; Vaccine adjuvants.

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Vaccination in the elderly: The challenge of immune changes with aging

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Vaccination in the elderly: The challenge of immune changes with aging

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