Expression and regulatory networks of Mycobacterium tuberculosis PE/PPE family antigens

doi:10.1002/jcp.27608

Review

. 2019 Jun;234(6):7742-7751.

doi: 10.1002/jcp.27608. Epub 2018 Nov 27.

Expression and regulatory networks of Mycobacterium tuberculosis PE/PPE family antigens

Wu Li¹, Wanyan Deng², Jianping Xie³

Affiliations

¹ Key Laboratory of Regional Characteristic Agricultural Resources, College of Life Sciences, Neijiang Normal University, Neijiang, China.
² Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.
³ Institute of Modern Biopharmaceuticals, State Key Laboratory Breeding Base of Eco-Environment and Bio-Resource of the Three Gorges Area, Key Laboratory of Eco-environments in Three Gorges Reservoir Region, Ministry of Education, School of Life Sciences, Southwest University, Beibei, Chongqing, China.

PMID: 30478834
DOI: 10.1002/jcp.27608

Review

Expression and regulatory networks of Mycobacterium tuberculosis PE/PPE family antigens

Wu Li et al. J Cell Physiol. 2019 Jun.

. 2019 Jun;234(6):7742-7751.

doi: 10.1002/jcp.27608. Epub 2018 Nov 27.

Authors

Wu Li¹, Wanyan Deng², Jianping Xie³

Affiliations

¹ Key Laboratory of Regional Characteristic Agricultural Resources, College of Life Sciences, Neijiang Normal University, Neijiang, China.
² Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.
³ Institute of Modern Biopharmaceuticals, State Key Laboratory Breeding Base of Eco-Environment and Bio-Resource of the Three Gorges Area, Key Laboratory of Eco-environments in Three Gorges Reservoir Region, Ministry of Education, School of Life Sciences, Southwest University, Beibei, Chongqing, China.

PMID: 30478834
DOI: 10.1002/jcp.27608

Abstract

PE/PPE family antigens are distributed mainly in pathogenic mycobacteria and serve as potential antituberculosis (TB) vaccine components. Some PE/PPE family antigens can regulate the host innate immune response, interfere with macrophage activation and phagolysosome fusion, and serve as major sources of antigenic variation. PE/PPE antigens have been associated with mycobacteria pathogenesis; pe/ppe genes are mainly found in pathogenic mycobacteria and are differentially expressed between Mtb and Mycobacterium bovis. PE/PPE proteins were essential for the growth of Mtb, and PE/PPE proteins were differentially expressed under a variety of conditions. Multiple mycobacterial-virulence-related transcription factors, sigma factors, the global transcriptional regulation factor Lsr2, MprAB, and PhoPR two-component regulatory systems, and cyclic adenine monophosphate-dependent regulators, regulate the expression of PE/PPE family antigens. Multiple-scale integrative analysis revealed the expression and regulatory networks of PE/PPE family antigens underlying the virulence and pathogenesis of Mtb, providing important clues for the discovery of new anti-TB measures.

Keywords: Mycobacterium tuberculosis; PE/PPE; expression pattern; multi-scale analyses; regulatory network.

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Expression and regulatory networks of Mycobacterium tuberculosis PE/PPE family antigens

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Expression and regulatory networks of Mycobacterium tuberculosis PE/PPE family antigens

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