All (animal) models (of neurodegeneration) are wrong. Are they also useful?

doi:10.1084/jem.20182042

. 2018 Dec 3;215(12):2955-2958.

doi: 10.1084/jem.20182042. Epub 2018 Nov 20.

All (animal) models (of neurodegeneration) are wrong. Are they also useful?

Richard M Ransohoff^{1

2}

Affiliations

¹ Third Rock Ventures, Boston, MA rransohoff@thirdrockventures.com.
² Department of Cell Biology, Harvard Medical School, Boston, MA.

PMID: 30459159
PMCID: PMC6279414
DOI: 10.1084/jem.20182042

All (animal) models (of neurodegeneration) are wrong. Are they also useful?

Richard M Ransohoff. J Exp Med. 2018.

. 2018 Dec 3;215(12):2955-2958.

doi: 10.1084/jem.20182042. Epub 2018 Nov 20.

Author

Richard M Ransohoff^{1

2}

Affiliations

¹ Third Rock Ventures, Boston, MA rransohoff@thirdrockventures.com.
² Department of Cell Biology, Harvard Medical School, Boston, MA.

PMID: 30459159
PMCID: PMC6279414
DOI: 10.1084/jem.20182042

Abstract

Richard M. Ransohoff, Entrepreneur-in-Residence at Third Rock Ventures and Visiting Scientist at Harvard Medical School, provides his personal opinion on using animal models to address current challenges and opportunities in drug development for neurodegeneration.

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Figures

None — Use of animal models across the process of drug development. The cartoon indicates selected stages of drug development for which animal models may be applied. ADME: Absorption, Distribution, Metabolism, and Excretion.

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References

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[1] Andorfer C., et al. . 2003. J. Neurochem. 86:582–590. 10.1046/j.1471-4159.2003.01879.x - DOI - PubMed

[2] Andorfer C., et al. . 2003. J. Neurochem. 86:582–590. 10.1046/j.1471-4159.2003.01879.x - DOI - PubMed

[3] Box G.E.P. 1979. Robustness in the strategy of scientific model building. In Robustness in Statistics. 10.1016/B978-0-12-438150-6.50018-2 - DOI

[4] Box G.E.P. 1979. Robustness in the strategy of scientific model building. In Robustness in Statistics. 10.1016/B978-0-12-438150-6.50018-2 - DOI

[5] Brettschneider J., et al. . 2015. Nat. Rev. Neurosci. 16:109–120. 10.1038/nrn3887 - DOI - PMC - PubMed

[6] Brettschneider J., et al. . 2015. Nat. Rev. Neurosci. 16:109–120. 10.1038/nrn3887 - DOI - PMC - PubMed

[7] Castellano J.M., et al. . 2011. Sci. Transl. Med. 3:89ra57 10.1126/scitranslmed.3002156 - DOI - PMC - PubMed

[8] Castellano J.M., et al. . 2011. Sci. Transl. Med. 3:89ra57 10.1126/scitranslmed.3002156 - DOI - PMC - PubMed

[9] Cummings J., et al. . 2018a Alzheimers Dement. (N. Y.). 4:195–214. 10.1016/j.trci.2018.03.009 - DOI - PMC - PubMed

[10] Cummings J., et al. . 2018a Alzheimers Dement. (N. Y.). 4:195–214. 10.1016/j.trci.2018.03.009 - DOI - PMC - PubMed

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All (animal) models (of neurodegeneration) are wrong. Are they also useful?

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All (animal) models (of neurodegeneration) are wrong. Are they also useful?

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