Evaluation and Management of Youth-Onset Type 2 Diabetes: A Position Statement by the American Diabetes Association

doi:10.2337/dci18-0052

Review

. 2018 Dec;41(12):2648-2668.

doi: 10.2337/dci18-0052.

Evaluation and Management of Youth-Onset Type 2 Diabetes: A Position Statement by the American Diabetes Association

Silva Arslanian^{1

2}, Fida Bacha³, Margaret Grey^{4

5}, Marsha D Marcus⁶, Neil H White⁷, Philip Zeitler⁸

Affiliations

¹ Division of Pediatric Endocrinology, Metabolism, and Diabetes Mellitus, University of Pittsburgh, Pittsburgh, PA silva.arslanian@chp.edu.
² Center for Pediatric Research in Obesity and Metabolism, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA.
³ Children's Nutrition Research Center, Texas Children's Hospital and Baylor College of Medicine, Houston, TX.
⁴ Yale School of Nursing, New Haven, CT.
⁵ Yale School of Medicine, New Haven, CT.
⁶ University of Pittsburgh School of Medicine, Pittsburgh, PA.
⁷ Washington University School of Medicine in St. Louis, St. Louis, MO.
⁸ Children's Hospital Colorado and University of Colorado School of Medicine, Aurora, CO.

PMID: 30425094
PMCID: PMC7732108
DOI: 10.2337/dci18-0052

Review

Evaluation and Management of Youth-Onset Type 2 Diabetes: A Position Statement by the American Diabetes Association

Silva Arslanian et al. Diabetes Care. 2018 Dec.

. 2018 Dec;41(12):2648-2668.

doi: 10.2337/dci18-0052.

Authors

Silva Arslanian^{1

2}, Fida Bacha³, Margaret Grey^{4

5}, Marsha D Marcus⁶, Neil H White⁷, Philip Zeitler⁸

Affiliations

¹ Division of Pediatric Endocrinology, Metabolism, and Diabetes Mellitus, University of Pittsburgh, Pittsburgh, PA silva.arslanian@chp.edu.
² Center for Pediatric Research in Obesity and Metabolism, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA.
³ Children's Nutrition Research Center, Texas Children's Hospital and Baylor College of Medicine, Houston, TX.
⁴ Yale School of Nursing, New Haven, CT.
⁵ Yale School of Medicine, New Haven, CT.
⁶ University of Pittsburgh School of Medicine, Pittsburgh, PA.
⁷ Washington University School of Medicine in St. Louis, St. Louis, MO.
⁸ Children's Hospital Colorado and University of Colorado School of Medicine, Aurora, CO.

PMID: 30425094
PMCID: PMC7732108
DOI: 10.2337/dci18-0052

No abstract available

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Figures

**Figure 1**
Management of new-onset diabetes in overweight youth suspected to have type 2 diabetes based on risk factors listed in Table 1. MDI, multiple daily injections.

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References

1. Kahn SE, Prigeon RL, McCulloch DK, et al. . Quantification of the relationship between insulin sensitivity and beta-cell function in human subjects. Evidence for a hyperbolic function. Diabetes 1993;42:1663–1672 - PubMed
1. Gungor N, Bacha F, Saad R, Janosky J, Arslanian S. Youth type 2 diabetes: insulin resistance, beta-cell failure, or both? Diabetes Care 2005;28:638–644 - PMC - PubMed
1. Michaliszyn SF, Mari A, Lee S, et al. . β-Cell function, incretin effect, and incretin hormones in obese youth along the span of glucose tolerance from normal to prediabetes to type 2 diabetes. Diabetes 2014;63:3846–3855 - PMC - PubMed
1. Umpierrez GE. (Ed.). Therapy for Diabetes Mellitus and Related Disorders. 6th ed. Alexandria, VA, American Diabetes Association, 2014
1. Bacha F, Lee S, Gungor N, Arslanian SA. From pre-diabetes to type 2 diabetes in obese youth: pathophysiological characteristics along the spectrum of glucose dysregulation. Diabetes Care 2010;33:2225–2231 - PMC - PubMed

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[1] Kahn SE, Prigeon RL, McCulloch DK, et al. . Quantification of the relationship between insulin sensitivity and beta-cell function in human subjects. Evidence for a hyperbolic function. Diabetes 1993;42:1663–1672 - PubMed

[2] Kahn SE, Prigeon RL, McCulloch DK, et al. . Quantification of the relationship between insulin sensitivity and beta-cell function in human subjects. Evidence for a hyperbolic function. Diabetes 1993;42:1663–1672 - PubMed

[3] Gungor N, Bacha F, Saad R, Janosky J, Arslanian S. Youth type 2 diabetes: insulin resistance, beta-cell failure, or both? Diabetes Care 2005;28:638–644 - PMC - PubMed

[4] Gungor N, Bacha F, Saad R, Janosky J, Arslanian S. Youth type 2 diabetes: insulin resistance, beta-cell failure, or both? Diabetes Care 2005;28:638–644 - PMC - PubMed

[5] Michaliszyn SF, Mari A, Lee S, et al. . β-Cell function, incretin effect, and incretin hormones in obese youth along the span of glucose tolerance from normal to prediabetes to type 2 diabetes. Diabetes 2014;63:3846–3855 - PMC - PubMed

[6] Michaliszyn SF, Mari A, Lee S, et al. . β-Cell function, incretin effect, and incretin hormones in obese youth along the span of glucose tolerance from normal to prediabetes to type 2 diabetes. Diabetes 2014;63:3846–3855 - PMC - PubMed

[7] Umpierrez GE. (Ed.). Therapy for Diabetes Mellitus and Related Disorders. 6th ed. Alexandria, VA, American Diabetes Association, 2014

[8] Umpierrez GE. (Ed.). Therapy for Diabetes Mellitus and Related Disorders. 6th ed. Alexandria, VA, American Diabetes Association, 2014

[9] Bacha F, Lee S, Gungor N, Arslanian SA. From pre-diabetes to type 2 diabetes in obese youth: pathophysiological characteristics along the spectrum of glucose dysregulation. Diabetes Care 2010;33:2225–2231 - PMC - PubMed

[10] Bacha F, Lee S, Gungor N, Arslanian SA. From pre-diabetes to type 2 diabetes in obese youth: pathophysiological characteristics along the spectrum of glucose dysregulation. Diabetes Care 2010;33:2225–2231 - PMC - PubMed

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Evaluation and Management of Youth-Onset Type 2 Diabetes: A Position Statement by the American Diabetes Association

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Evaluation and Management of Youth-Onset Type 2 Diabetes: A Position Statement by the American Diabetes Association

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