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Meta-Analysis
. 2018 Nov 13;9(11):203.
doi: 10.1038/s41424-018-0070-z.

Prognostic Value of MicroRNAs in Esophageal Carcinoma: A Meta-Analysis

Song Gao  1 , Zhi-Ying Zhao  2 , Zhen-Yong Zhang  1 , Yue Zhang  3 , Rong Wu  4
Affiliations
Meta-Analysis

Prognostic Value of MicroRNAs in Esophageal Carcinoma: A Meta-Analysis

Song Gao et al. Clin Transl Gastroenterol. .

Abstract

Background: Numerous articles have reported that abnormal expression levels of microRNAs (miRNAs) are related to the survival times of esophageal carcinoma (EC) patients, which contains esophageal adenocarcinoma (EAC) and esophageal squamous cell carcinoma (ESCC). Nevertheless, there has not been a comprehensive meta-analysis to assess the accurate prognostic value of miRNAs in EC.

Methods: Studies published in English up to April 12, 2018 that evaluated the correlation of the expression levels of miRNAs with overall survival (OS) in EC were identified by online searches in PubMed, EMBASE, Web of Science, and the Cochrane Database of Systematic Reviews performed by two independent authors. The pooled hazard ratios (HRs) with 95% confidence intervals (CIs) were used to estimate the correlation between OS and miRNA expression. HR ≥ 2 was considered cutoff for considering the miRNA as prognostic candidate.

Results: Forty-four pertinent articles with 22 miRNAs and 4310 EC patients were ultimately included. EC patients with tissue expression levels of high miR-21 or low miR-133a (HR = 2.48, 95% CI = 1.50-4.12), miR-133b (HR = 2.15, 95% CI = 1.27-3.62), miR-138 (HR = 2.27, 95% CI = 1.68-3.08), miR-203 (HR = 2.83, 95% CI = 1.35-5.95), miR-375 and miR-655 (HR = 2.66, 95% CI = 1.16-6.12) had significantly poorer OS (P < 0.05). In addition, EC patients with blood expression levels of high miR-21 (HR = 2.19, 95% CI = 1.31-3.68) and miR-223 had significantly shorter OS (P < 0.05).

Conclusions: In conclusion, tissue expression levels of miR-21, miR-133a, miR-133b, miR-138, miR-203, miR-375, and miR-655 and blood expression levels of miR-21 and miR-223 demonstrate significant prognostic value. Among them, the expression levels of miR-133a, miR-133b, miR-138, miR-203, and miR-655 in tissue and the expression level of miR-21 in blood are potential prognostic candidates for predicting OS in EC.

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Conflict of interest statement

Guarantor of article: Yue Zhang

Specific author contributions: Study concept and design: Y.Z. Acquisition of data: S.G. and Z.-Y. Zhao. Analysis and interpretation of data: S.G., Z.-Y. Zhao and Z.-Y. Zhang. Drafting of the manuscript: Y.Z. Revision of manuscript: S.G., Z.-Y. Zhao, Z.-Y. Zhang, Y.Z. and R.W. Supervision of work: Y.Z. and R.W. All authors read and approved the final manuscript.

Financial support: None.

Potential competing interests: None.

Figures

Fig. 1
Fig. 1
Flow diagram of the literature search and selection
Fig. 2
Fig. 2
Forest plot of pooled analyses of OS in association with tissue expression levels of low miR-133a, miR-133b, miR-138, miR-203, and miR-605 and blood expression levels of high miR-21
Fig. 3
Fig. 3
Summary of microRNAs with altered expression, potential targets, and pathways entered in this study. E-cadherin cadherin 1, type 1, E-cadherin (epithelial), PDCD4 programmed cell death 4, MTDH metadherin, CDH1 cadherin 1, mTOR mechanistic target of rapamycin kinase, FLOT1 flotillin 1, FLOT2 flotillin 2, PTEN phosphatase and tensin homolog, MMP10 matrix metallopeptidase 10, FBXW7 F-box and WD repeat domain containing 7, IGF1R insulin like growth factor 1 receptor, FAM83F family with sequence similarity 83 member F, DKK3 dickkopf WNT signaling pathway inhibitor 3, GSK3β glycogen synthase kinase 3 beta, Smurf2 SMAD specific E3 ubiquitin protein ligase 2, PPM1A protein phosphatase, Mg2+/Mn2+ dependent 1A, PTTG1 pituitary tumor-transforming 1, ZEB1 zinc finger E-box binding homeobox 1, TGFBR2 transforming growth factor beta receptor 2, NF-kB nuclear factor-kappaB, PI3K phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta, AKT AKT serine/threonine kinase 1, TGF-β transforming growth factor-β
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