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Comparative Study
. 1988 Aug;85(15):5507-11.
doi: 10.1073/pnas.85.15.5507.

Inhibition of human immunodeficiency virus replication by antisense oligodeoxynucleotides

J Goodchild  1 , S Agrawal, M P Civeira, P S Sarin, D Sun, P C Zamecnik
Affiliations
Comparative Study

Inhibition of human immunodeficiency virus replication by antisense oligodeoxynucleotides

J Goodchild et al. Proc Natl Acad Sci U S A. 1988 Aug.

Erratum in

  • Proc Natl Acad Sci U S A 1989 Mar;86(5):1504

Abstract

Twenty different target sites within human immunodeficiency virus (HIV) RNA were selected for studies of inhibition of HIV replication by antisense oligonucleotides. Target sites were selected based on their potential capacity to block recognition functions during viral replication. Antisense oligomers complementary to sites within or near the sequence repeated at the ends of retrovirus RNA (R region) and to certain splice sites were most effective. The effect of antisense oligomer length on inhibiting virus replication was also investigated, and preliminary toxicity studies in mice show that these compounds are toxic only at high levels. The results indicate potential usefulness for these oligomers in the treatment of patients with acquired immunodeficiency syndrome (AIDS) and AIDS-related complex either alone or in combination with other drugs.

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References

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