Review
doi: 10.3881/j.issn.1000-503X.10208.
[TWIK-related Acid Sensitive K + Channels in the Regulation of Respiration and Sleep]
[Article in
Chinese]
Affiliations
- PMID: 30404704
- DOI: 10.3881/j.issn.1000-503X.10208
Item in Clipboard
Review
[TWIK-related Acid Sensitive K + Channels in the Regulation of Respiration and Sleep]
[Article in
Chinese]
Zhongguo Yi Xue Ke Xue Yuan Xue Bao.
.
Abstract
TWIK-related acid-sensitive K + channel(TASK)is an important member of the two-pore-domain potassium channels family. It is widely expressed in the central nervous system and peripheral tissues and is extremely sensitive to hypoxia and pH changes in extracellular fluid. TASK participates in regulating the expression of respiratory center and the respiratory movement and also plays certain role in sleep regulation. This article reviews the recent advances in the roles of TASK in the regulation of respiration and sleep.
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