Comparative Study
doi: 10.1093/jac/19.5.663.
Efficacy of fluconazole (UK-49,858) against experimental aspergillosis and cryptococcosis in mice
- PMID: 3038824
- DOI: 10.1093/jac/19.5.663
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Comparative Study
Efficacy of fluconazole (UK-49,858) against experimental aspergillosis and cryptococcosis in mice
J Antimicrob Chemother.
1987 May.
Abstract
The efficacy of fluconazole, a new bis-triazole antifungal agent, was compared with that of orally administered ketoconazole and parenterally administered amphotericin B against aspergillus and cryptococcus infections in mice. Fluconazole was 5-20-fold more active than ketoconazole against systemic aspergillosis and against systemic, intracranial and pulmonary cryptococcosis but was less active than amphotericin B.
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