Mechanisms of synergistic neurotoxicity induced by two high risk pesticide residues - Chlorpyrifos and Carbofuran via oxidative stress

doi:10.1016/j.tiv.2018.10.016

. 2019 Feb:54:338-344.

doi: 10.1016/j.tiv.2018.10.016. Epub 2018 Oct 30.

Mechanisms of synergistic neurotoxicity induced by two high risk pesticide residues - Chlorpyrifos and Carbofuran via oxidative stress

Dong-Jun Fu¹, Ping Li¹, Jian Song¹, Sai-Yang Zhang², Han-Zhong Xie³

Affiliations

¹ New Drug Research & Development Center, School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China; Collaborative Innovation Center of New Drug Research and Safety Evaluation, Zhengzhou 450001, China; Key Laboratory of Technology of Drug Preparation, Zhengzhou University, Ministry of Education, Zhengzhou 450001, China; Key Laboratory of Henan Province for Drug Quality and Evaluation, Zhengzhou 450001, China.
² Zhengzhou Fruit Research Institute China Chinese Academy of Agricultural Sciences, Zhengzhou 450009, China; School of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450001, China; New Drug Research & Development Center, School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China; Collaborative Innovation Center of New Drug Research and Safety Evaluation, Zhengzhou 450001, China; Key Laboratory of Technology of Drug Preparation, Zhengzhou University, Ministry of Education, Zhengzhou 450001, China; Key Laboratory of Henan Province for Drug Quality and Evaluation, Zhengzhou 450001, China; Henan Institutes of Advanced Technology, Zhengzhou University, Zhengzhou 450001, China; Henan Key Laboratory of Fruit and Cucurbit Biology, Zhengzhou 450009, China. Electronic address: saiyangz@zzu.edu.cn.
³ Zhengzhou Fruit Research Institute China Chinese Academy of Agricultural Sciences, Zhengzhou 450009, China; Henan Key Laboratory of Fruit and Cucurbit Biology, Zhengzhou 450009, China. Electronic address: xiehanzhong@caas.cn.

PMID: 30385350
DOI: 10.1016/j.tiv.2018.10.016

Mechanisms of synergistic neurotoxicity induced by two high risk pesticide residues - Chlorpyrifos and Carbofuran via oxidative stress

Dong-Jun Fu et al. Toxicol In Vitro. 2019 Feb.

. 2019 Feb:54:338-344.

doi: 10.1016/j.tiv.2018.10.016. Epub 2018 Oct 30.

Authors

Dong-Jun Fu¹, Ping Li¹, Jian Song¹, Sai-Yang Zhang², Han-Zhong Xie³

Affiliations

¹ New Drug Research & Development Center, School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China; Collaborative Innovation Center of New Drug Research and Safety Evaluation, Zhengzhou 450001, China; Key Laboratory of Technology of Drug Preparation, Zhengzhou University, Ministry of Education, Zhengzhou 450001, China; Key Laboratory of Henan Province for Drug Quality and Evaluation, Zhengzhou 450001, China.
² Zhengzhou Fruit Research Institute China Chinese Academy of Agricultural Sciences, Zhengzhou 450009, China; School of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450001, China; New Drug Research & Development Center, School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China; Collaborative Innovation Center of New Drug Research and Safety Evaluation, Zhengzhou 450001, China; Key Laboratory of Technology of Drug Preparation, Zhengzhou University, Ministry of Education, Zhengzhou 450001, China; Key Laboratory of Henan Province for Drug Quality and Evaluation, Zhengzhou 450001, China; Henan Institutes of Advanced Technology, Zhengzhou University, Zhengzhou 450001, China; Henan Key Laboratory of Fruit and Cucurbit Biology, Zhengzhou 450009, China. Electronic address: saiyangz@zzu.edu.cn.
³ Zhengzhou Fruit Research Institute China Chinese Academy of Agricultural Sciences, Zhengzhou 450009, China; Henan Key Laboratory of Fruit and Cucurbit Biology, Zhengzhou 450009, China. Electronic address: xiehanzhong@caas.cn.

PMID: 30385350
DOI: 10.1016/j.tiv.2018.10.016

Abstract

Multi-component pesticide residues, especially pesticide residues with synergistic toxicity, are a serious threat to food safety. With risk assessment, we found that Chlorpyrifos (CPF) and Carbofuran (CBF) are 2 pesticide residues with highest risk for Actinidia chinensis planch. The results showed CPF and CBF have a synergistic neurotoxicity on neural cell SK-N-SH. The toxicity was partly depending on oxidative stress (OS) and had effects on cell apoptosis and cell cycle arrest. Furthermore, the toxicity remained on long-term low-dose condition.

Keywords: Apoptosis; Carbofuran; Chlorpyrifos; Cycle arrest; Oxidative stress; Synergistic neurotoxicity.

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Mechanisms of synergistic neurotoxicity induced by two high risk pesticide residues - Chlorpyrifos and Carbofuran via oxidative stress

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Mechanisms of synergistic neurotoxicity induced by two high risk pesticide residues - Chlorpyrifos and Carbofuran via oxidative stress

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