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Observational Study
. 2018 Nov;97(44):e12926.
doi: 10.1097/MD.0000000000012926.

Evaluation of the association between hyperuricemia and coronary artery disease: A STROBE-compliant article

Ming Lan  1 , Bing Liu, Qing He
Affiliations
Observational Study

Evaluation of the association between hyperuricemia and coronary artery disease: A STROBE-compliant article

Ming Lan et al. Medicine (Baltimore). 2018 Nov.

Abstract

The aim of the study was to assess the independent contribution of hyperuricemia to coronary artery disease (CAD) confirmed by coronary angiography (CAG), and to explore associations between serum uric acid (SUA) level and CAD.We performed a retrospective cohort study of 5069 patients who underwent CAG. Patients were divided into groups: hyperuricemia (n = 1178) versus nonhyperuricemia (n = 3891) and CAD (n = 3433) versus non-CAD (n = 1636).The incidence of CAD was higher in the hyperuricemia group than in the nonhyperuricemia group (71.5% vs 66.6%, P = .002). Hyperuricemia and CAD were significantly correlated in women (odds ratio = 1.509, 95% confidence interval, 1.106-2.057, P = .009). And there were trends, higher SUA quartiles were associated with higher percentage of CAD (62.3%, 68.0%, 68.9%, and 71.7% for quartiles 1, 2, 3, and 4, respectively, P < .001), and the incidence of 3-vessel disease increased (25.2%, 26.4%, 27.2%, and 31.1% for quartiles 1, 2, 3, and 4, respectively, P = .001) and that of normal vessel decreased (37.7%, 32.0%, 31.1%, and 28.3% for quartiles 1, 2, 3, and 4, respectively, P < .001) across quartiles, these trends were found in female group, but not in male group. The SUA level significantly increased as the number of diseased vessels increased (P < .001).There was an independent correlation between hyperuricemia and CAD in women. A higher SUA level was associated with a higher incidence of 3-vessel disease in women.

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Conflict of interest statement

The authors have no conflicts of interest to disclose.

Figures

Figure 1
Figure 1
Prevalence of coronary artery disease (CAD) according to serum uric acid quartiles. After stratifying the patients into 4 groups according to their SUA quartiles, a trend was found that higher SUA quartiles were associated with higher percentage of CAD. The values were significantly different as a whole, and the incidence of CAD in quartile 1 was significantly different with any one of the other quartiles, but no significant difference was found among quartiles 2, 3, and 4.
Figure 2
Figure 2
Number of vessels affected in different serum uric acid levels. The higher SUA quartiles were associated with higher incidence of 3-vessel disease, and the higher SUA quartiles were associated with lower incidence of normal vessel. And the incidence of 3-vessel in quartile 4 was significantly different as compared with those in other quartiles, but no significant difference was found among quartiles 1, 2, and 3; furthermore, the incidence of normal vessel in quartile 1 was significantly different with those of any other quartiles, and significant difference was also found between quartile 2 and 4, but no significant difference was found among other quartiles.
Figure 3
Figure 3
Mean serum uric acid level in groups with different numbers of vessels affected. The SUA level significantly increased as the number of affected vessels increased.
See this image and copyright information in PMC

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