Heart-Breaking Telomeres
- PMID: 30355079
- DOI: 10.1161/CIRCRESAHA.118.312202
Heart-Breaking Telomeres
Abstract
Telomeres, the protective ends of linear chromosomes, shorten throughout an individual's lifetime. Accumulation of critically short telomeres is proposed to be a primary molecular cause of aging and age-associated diseases. Mutations in telomere maintenance genes are associated with pathologies referred to as or telomeropathies. The rate of telomere shortening throughout life is determined by endogenous (genetic) and external (nongenetic) factors. Therapeutic strategies based on telomerase activation are being developed to treat and prevent telomere-associated diseases, namely aging-related diseases and telomeropathies. Here, we review the molecular mechanisms underlying telomere driven diseases with particular emphasis on cardiovascular diseases.
Keywords: cardiovascular diseases; mutation; telomerase; telomere shortening; telomeres.
Similar articles
-
Telomere-driven diseases and telomere-targeting therapies.J Cell Biol. 2017 Apr 3;216(4):875-887. doi: 10.1083/jcb.201610111. Epub 2017 Mar 2. J Cell Biol. 2017. PMID: 28254828 Free PMC article. Review.
-
Telomere length variations in aging and age-related diseases.Curr Aging Sci. 2014;7(3):161-7. doi: 10.2174/1874609808666150122153151. Curr Aging Sci. 2014. PMID: 25612739 Review.
-
Telomere Length as Cardiovascular Aging Biomarker: JACC Review Topic of the Week.J Am Coll Cardiol. 2018 Aug 14;72(7):805-813. doi: 10.1016/j.jacc.2018.06.014. J Am Coll Cardiol. 2018. PMID: 30092957 Review.
-
Telomeres and telomerase as therapeutic targets to prevent and treat age-related diseases.F1000Res. 2016 Jan 20;5:F1000 Faculty Rev-89. doi: 10.12688/f1000research.7020.1. eCollection 2016. F1000Res. 2016. PMID: 27081482 Free PMC article. Review.
-
Inflammation and Vascular Ageing: From Telomeres to Novel Emerging Mechanisms.High Blood Press Cardiovasc Prev. 2019 Aug;26(4):321-329. doi: 10.1007/s40292-019-00331-7. Epub 2019 Jul 19. High Blood Press Cardiovasc Prev. 2019. PMID: 31325087 Review.
Cited by
-
Born to Age: When Adult Congenital Heart Disease Converges With Geroscience.JACC Adv. 2022 Mar 18;1(1):100012. doi: 10.1016/j.jacadv.2022.100012. eCollection 2022 Mar. JACC Adv. 2022. PMID: 38939088 Free PMC article. Review.
-
TRF2 rescues telomere attrition and prolongs cell survival in Duchenne muscular dystrophy cardiomyocytes derived from human iPSCs.Proc Natl Acad Sci U S A. 2023 Feb 7;120(6):e2209967120. doi: 10.1073/pnas.2209967120. Epub 2023 Jan 31. Proc Natl Acad Sci U S A. 2023. PMID: 36719921 Free PMC article.
-
Genetically Predicted Longer Telomere Length May Reduce Risk of Hip Osteoarthritis.Front Genet. 2021 Oct 5;12:718890. doi: 10.3389/fgene.2021.718890. eCollection 2021. Front Genet. 2021. PMID: 34675961 Free PMC article.
-
Causal Association of Telomere Length and Loss of Bone: a Directional Mendelian Randomization Study of Multi-Outcomes.Appl Biochem Biotechnol. 2024 Oct;196(10):7045-7063. doi: 10.1007/s12010-024-04899-2. Epub 2024 Mar 13. Appl Biochem Biotechnol. 2024. PMID: 38478320
-
3D Super-Resolution Nuclear Q-FISH Imaging Reveals Cell-Cycle-Related Telomere Changes.Int J Mol Sci. 2024 Mar 10;25(6):3183. doi: 10.3390/ijms25063183. Int J Mol Sci. 2024. PMID: 38542157 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical