doi: 10.1099/0022-1317-68-6-1761.
Latent herpes simplex virus type 1 DNA is not extensively methylated in vivo
- PMID: 3035069
- DOI: 10.1099/0022-1317-68-6-1761
Item in Clipboard
Latent herpes simplex virus type 1 DNA is not extensively methylated in vivo
J Gen Virol.
1987 Jun.
Abstract
The methylation pattern of herpes simplex virus type 1 (HSV-1) DNA, present in the central nervous system of latently infected mice, was examined by digestion of the DNA with methylation-sensitive restriction endonucleases and Southern blot hybridization. Using the enzymes SmaI, XmaI, SalI and SacII, the data indicate no extensive methylation of latent HSV-1 DNA in vivo. Thus, extensive methylation of the viral genome is not a necessary condition for, or a consequence of maintaining, the latent state in vivo.
Similar articles
-
Latent herpes simplex virus type 1 transcripts in peripheral and central nervous system tissues of mice map to similar regions of the viral genome.J Virol. 1988 Mar;62(3):749-56. doi: 10.1128/JVI.62.3.749-756.1988. J Virol. 1988. PMID: 2828670 Free PMC article.
-
Does restriction enzyme analysis reveal changes in herpes simplex virus DNA after latency in mouse ganglia?Microbiologica. 1986 Apr;9(2):139-45. Microbiologica. 1986. PMID: 3012286
-
Neuronal control of herpes simplex virus latency.Virology. 1993 Aug;195(2):337-47. doi: 10.1006/viro.1993.1384. Virology. 1993. PMID: 8393231
-
Transcripts associated with herpes simplex virus latency.Adv Exp Med Biol. 1990;278:199-204. doi: 10.1007/978-1-4684-5853-4_20. Adv Exp Med Biol. 1990. PMID: 1963035 Review. No abstract available.
-
Latent herpes simplex virus and the nervous system,Curr Top Microbiol Immunol. 1975;70:31-50. doi: 10.1007/978-3-642-66101-3_2. Curr Top Microbiol Immunol. 1975. PMID: 169103 Review. No abstract available.
Cited by
-
Genomic organization and evolution of the human herpesviruses.Virus Genes. 1998;16(1):85-93. doi: 10.1023/a:1007905910939. Virus Genes. 1998. PMID: 9562893 Review.
-
Targeted DNA mutagenesis for the cure of chronic viral infections.J Virol. 2012 Sep;86(17):8920-36. doi: 10.1128/JVI.00052-12. Epub 2012 Jun 20. J Virol. 2012. PMID: 22718830 Free PMC article. Review.
-
Enhanced in vitro reactivation of latent herpes simplex virus from neural and peripheral tissues with hexamethylenebisacetamide.Arch Virol. 1988;99(1-2):57-65. doi: 10.1007/BF01311023. Arch Virol. 1988. PMID: 2833203
-
Histone deacetylase inhibitors induce reactivation of herpes simplex virus type 1 in a latency-associated transcript-independent manner in neuronal cells.J Neurovirol. 2005 Jul;11(3):306-17. doi: 10.1080/13550280590952817. J Neurovirol. 2005. PMID: 16036811 Free PMC article.
-
Role of Herpes Simplex Virus Type 1 (HSV-1) Glycoprotein K (gK) Pathogenic CD8+ T Cells in Exacerbation of Eye Disease.Front Immunol. 2018 Dec 7;9:2895. doi: 10.3389/fimmu.2018.02895. eCollection 2018. Front Immunol. 2018. PMID: 30581441 Free PMC article. Review.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
