Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1987 Apr;60(4):481-4.

Induction of secondary immune response by reactivated Japanese encephalitis virus in latently infected mice

A Mathur, R Kulshreshtha, U C Chaturvedi

Induction of secondary immune response by reactivated Japanese encephalitis virus in latently infected mice

A Mathur et al. Immunology. 1987 Apr.

Abstract

Development of secondary immune response has been studied following reactivation of latent Japanese encephalitis virus (JEV) infection in mice. The virus could be reactivated in 43% of the latently infected mice at 27 weeks p.i. by treatment with cyclophosphamide. The reactivated virus induced delayed-type hypersensitivity (DTH) and leucocyte migration inhibition (LMI) responses in mice, with peak activity on Day 5 post-reactivation (p.r.). The DTH persisted at low levels for long periods. Humoral immunity measured by haemagglutination-inhibiting antibody showed a four-fold rise in antibody titres. DTH was transferable by immune spleen cells for 5 days p.r. only. It is, therefore, concluded that JEV reactivation generates a quick and short-lived secondary immune response.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. J Exp Med. 1971 Jul 1;134(1):66-82 - PubMed
    1. Nature. 1974 Apr 12;248(449):612-4 - PubMed
    1. J Immunol. 1976 Jan;116(1):35-40 - PubMed
    1. J Gen Virol. 1977 Sep;36(3):449-58 - PubMed
    1. J Virol. 1979 Sep;31(3):816-22 - PubMed

Publication types

Substances

LinkOut - more resources