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Review
. 2018 Nov:103:286-292.
doi: 10.1016/j.molimm.2018.09.024. Epub 2018 Oct 18.

Role of non-classical T cells in skin immunity

Joon Seok Park  1 , Ji Hyung Kim  2
Affiliations
Review

Role of non-classical T cells in skin immunity

Joon Seok Park et al. Mol Immunol. 2018 Nov.

Abstract

The immune network controls homeostasis and inflammation of the skin. Immune cells use their antigen receptors to respond to a wide range of insults originating from microbes and allergens. T cells, which are key effector cells in the immune system, engage their T cell receptors (TCRs) to recognize self and foreign antigens in the context of classical major histocompatibility complex (MHC) molecules, MHC-like CD1 proteins, or MHC class I-related molecules. Recently, increasing evidence has demonstrated that T cells activated by non-canonical antigens are important in skin diseases. This review focuses on recent studies examining the roles of non-classical antigen-presenting molecules and their reactive T cells in the skin immune system. Additionally, we describe the types of ligands that activate these unconventional T cells through the non-classical MHC pathway. Finally, we highlight recent advances in the understanding of the physiological functions of non-classical T cells in the skin. Further investigation may result in the development of new therapeutic strategies for treating immune-related skin diseases.

Keywords: Lipid antigen; Non-classical major histocompatibility complex molecules; Non-peptidyl antigen presentation; Skin inflammation; Unconventional T cell.

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