Anti-inflammatory and immune-regulatory cytokines in rheumatoid arthritis

doi:10.1038/s41584-018-0109-2

Review

. 2019 Jan;15(1):9-17.

doi: 10.1038/s41584-018-0109-2.

Anti-inflammatory and immune-regulatory cytokines in rheumatoid arthritis

Zhu Chen¹, Aline Bozec², Andreas Ramming², Georg Schett³

Affiliations

¹ Department of Rheumatology and Immunology, The First Affiliated Hospital of the University of Science and Technology of China, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
² Department of Internal Medicine 3, Friedrich Alexander University Erlangen-Nuremberg and Universitatsklinikum Erlangen, Erlangen, Germany.
³ Department of Internal Medicine 3, Friedrich Alexander University Erlangen-Nuremberg and Universitatsklinikum Erlangen, Erlangen, Germany. georg.schett@uk-erlangen.de.

PMID: 30341437
DOI: 10.1038/s41584-018-0109-2

Review

Anti-inflammatory and immune-regulatory cytokines in rheumatoid arthritis

Zhu Chen et al. Nat Rev Rheumatol. 2019 Jan.

. 2019 Jan;15(1):9-17.

doi: 10.1038/s41584-018-0109-2.

Authors

Zhu Chen¹, Aline Bozec², Andreas Ramming², Georg Schett³

Affiliations

¹ Department of Rheumatology and Immunology, The First Affiliated Hospital of the University of Science and Technology of China, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
² Department of Internal Medicine 3, Friedrich Alexander University Erlangen-Nuremberg and Universitatsklinikum Erlangen, Erlangen, Germany.
³ Department of Internal Medicine 3, Friedrich Alexander University Erlangen-Nuremberg and Universitatsklinikum Erlangen, Erlangen, Germany. georg.schett@uk-erlangen.de.

PMID: 30341437
DOI: 10.1038/s41584-018-0109-2

Abstract

Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by a failure of spontaneous resolution of inflammation. Although the pro-inflammatory cytokines and mediators that trigger RA have been the focus of intense investigations, the regulatory and anti-inflammatory cytokines responsible for the suppression and resolution of disease in a context-dependent manner have been less well characterized. However, knowledge of the pathways that control the suppression and resolution of inflammation in RA is clinically relevant and conceptually important for understanding the pathophysiology of the disease and for the development of treatments that enable long-term remission. Cytokine-mediated processes such as the activation of T helper 2 cells by IL-4 and IL-13, the resolution of inflammation by IL-9, IL-5-induced eosinophil expansion, IL-33-mediated macrophage polarization, the production of IL-10 by regulatory B cells and IL-27-mediated suppression of lymphoid follicle formation are all involved in governing the regulation and resolution of inflammation in RA. By better understanding these immune-regulatory signalling pathways, new therapeutic strategies for RA can be envisioned that aim to balance and resolve, rather than suppress, inflammation.

PubMed Disclaimer

Cited by

Clinical Evaluation of Collagen-Induced Arthritis in Female Lewis Rats: A Comprehensive Analysis of Disease Progression and Severity.
Babaahmadi M, Makvand Gholipour N, Tayebi B, Pheneger J, Hajizadeh-Saffar E, Baghaban Eslaminejad M, Hassani SN. Babaahmadi M, et al. Cell J. 2023 Dec 31;25(12):854-862. doi: 10.22074/cellj.2023.2004504.1326. Cell J. 2023. PMID: 38192256 Free PMC article.
Communications via the Small Leucine-rich Proteoglycans: Molecular Specificity in Inflammation and Autoimmune Diseases.
Zeng-Brouwers J, Pandey S, Trebicka J, Wygrecka M, Schaefer L. Zeng-Brouwers J, et al. J Histochem Cytochem. 2020 Dec;68(12):887-906. doi: 10.1369/0022155420930303. Epub 2020 Jul 6. J Histochem Cytochem. 2020. PMID: 32623933 Free PMC article. Review.
Network-Based In Silico Analysis of New Combinations of Modern Drug Targets with Methotrexate for Response-Based Treatment of Rheumatoid Arthritis.
Assefi M, Lewandrowski KU, Lorio M, Fiorelli RKA; Brazilian Society For Thoracic Surgery—Sociedade Brasileira de Cirurgia Torácica (SBCT); Landgraeber S, Sharafshah A. Assefi M, et al. J Pers Med. 2023 Oct 29;13(11):1550. doi: 10.3390/jpm13111550. J Pers Med. 2023. PMID: 38003865 Free PMC article. Review.
Microbe-Derived Antioxidants Reduce Lipopolysaccharide-Induced Inflammatory Responses by Activating the Nrf2 Pathway to Inhibit the ROS/NLRP3/IL-1β Signaling Pathway.
Shen C, Luo Z, Ma S, Yu C, Gao Q, Zhang M, Zhang H, Zhang J, Xu W, Yao J, Xu J. Shen C, et al. Int J Mol Sci. 2022 Oct 18;23(20):12477. doi: 10.3390/ijms232012477. Int J Mol Sci. 2022. PMID: 36293333 Free PMC article.
Punicalagin Inhibited Inflammation and Migration of Fibroblast-Like Synoviocytes Through NF-κB Pathway in the Experimental Study of Rheumatoid Arthritis.
Huang M, Wu K, Zeng S, Liu W, Cui T, Chen Z, Lin L, Chen D, Ouyang H. Huang M, et al. J Inflamm Res. 2021 May 12;14:1901-1913. doi: 10.2147/JIR.S302929. eCollection 2021. J Inflamm Res. 2021. PMID: 34012288 Free PMC article.

See all "Cited by" articles

References

1. McInnes, I. B. & Schett, G. The pathogenesis of rheumatoid arthritis. N. Engl. J. Med. 365, 2205–2219 (2011). - PubMed - DOI
1. Schett, G., Elewaut, D., McInnes, I. B., Dayer, J. M. & Neurath, M. F. How cytokine networks fuel inflammation: Toward a cytokine-based disease taxonomy. Nat. Med. 19, 822–824 (2013). - PubMed - DOI
1. McInnes, I. B. & Schett, G. Cytokines in the pathogenesis of rheumatoid arthritis. Nat. Rev. Immunol. 7, 429–442 (2007). - PubMed - DOI
1. Cascao, R., Rosario, H. S., Souto-Carneiro, M. M. & Fonseca, J. E. Neutrophils in rheumatoid arthritis: more than simple final effectors. Autoimmun. Rev. 9, 531–535 (2010). - PubMed - DOI
1. Hueber, A. J. et al. Mast cells express IL-17A in rheumatoid arthritis synovium. J. Immunol. 184, 3336–3340 (2010). - PubMed - DOI

Publication types

Actions
Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Substances

Actions
Actions
Actions

LinkOut - more resources

Full Text Sources
- Nature Publishing Group
Other Literature Sources
- The Lens - Patent Citations Database
Medical
- MedlinePlus Health Information

[1] McInnes, I. B. & Schett, G. The pathogenesis of rheumatoid arthritis. N. Engl. J. Med. 365, 2205–2219 (2011). - PubMed - DOI

[2] McInnes, I. B. & Schett, G. The pathogenesis of rheumatoid arthritis. N. Engl. J. Med. 365, 2205–2219 (2011). - PubMed - DOI

[3] Schett, G., Elewaut, D., McInnes, I. B., Dayer, J. M. & Neurath, M. F. How cytokine networks fuel inflammation: Toward a cytokine-based disease taxonomy. Nat. Med. 19, 822–824 (2013). - PubMed - DOI

[4] Schett, G., Elewaut, D., McInnes, I. B., Dayer, J. M. & Neurath, M. F. How cytokine networks fuel inflammation: Toward a cytokine-based disease taxonomy. Nat. Med. 19, 822–824 (2013). - PubMed - DOI

[5] McInnes, I. B. & Schett, G. Cytokines in the pathogenesis of rheumatoid arthritis. Nat. Rev. Immunol. 7, 429–442 (2007). - PubMed - DOI

[6] McInnes, I. B. & Schett, G. Cytokines in the pathogenesis of rheumatoid arthritis. Nat. Rev. Immunol. 7, 429–442 (2007). - PubMed - DOI

[7] Cascao, R., Rosario, H. S., Souto-Carneiro, M. M. & Fonseca, J. E. Neutrophils in rheumatoid arthritis: more than simple final effectors. Autoimmun. Rev. 9, 531–535 (2010). - PubMed - DOI

[8] Cascao, R., Rosario, H. S., Souto-Carneiro, M. M. & Fonseca, J. E. Neutrophils in rheumatoid arthritis: more than simple final effectors. Autoimmun. Rev. 9, 531–535 (2010). - PubMed - DOI

[9] Hueber, A. J. et al. Mast cells express IL-17A in rheumatoid arthritis synovium. J. Immunol. 184, 3336–3340 (2010). - PubMed - DOI

[10] Hueber, A. J. et al. Mast cells express IL-17A in rheumatoid arthritis synovium. J. Immunol. 184, 3336–3340 (2010). - PubMed - DOI

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Anti-inflammatory and immune-regulatory cytokines in rheumatoid arthritis

Affiliations

Anti-inflammatory and immune-regulatory cytokines in rheumatoid arthritis

Authors

Affiliations

Abstract

Similar articles

Cited by

References

Publication types

MeSH terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical