Role of GTPases in the Regulation of Mitochondrial Dynamics in Alzheimer's Disease and CNS-Related Disorders

doi:10.1007/s12035-018-1397-x

Review

. 2019 Jun;56(6):4530-4538.

doi: 10.1007/s12035-018-1397-x. Epub 2018 Oct 18.

Role of GTPases in the Regulation of Mitochondrial Dynamics in Alzheimer's Disease and CNS-Related Disorders

Athanasios Alexiou^{1

2}, Georgia Soursou³, Stylianos Chatzichronis^{4

5}, Ermis Gasparatos⁶, Mohammad Amjad Kamal^{7

8

9}, Nagendra Sastry Yarla¹⁰, Asma Perveen¹¹, George E Barreto^{12

13}, Ghulam Md Ashraf¹⁴

Affiliations

¹ Novel Global Community Educational Foundation, Hebersham, Australia. alexiou@ngcef.net.
² AFNP Med Austria, Haidingergasse 29, 1030, Wien, Austria. alexiou@ngcef.net.
³ Medical School, Bioinformatics Program, University of Crete, Heraklion, Greece.
⁴ AFNP Med Austria, Haidingergasse 29, 1030, Wien, Austria.
⁵ Department of Informatics and Telecommunications, Bioinformatics Program, National and Kapodistrian University of Athens, Athens, Greece.
⁶ Department of Psychology, City Unity College of Athens, Athens, Greece.
⁷ Novel Global Community Educational Foundation, Hebersham, Australia.
⁸ King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia.
⁹ Enzymoics, 7 Peterlee Place, Hebersham, NSW, 2770, Australia.
¹⁰ Department of Biochemistry and Bioinformatics, Institute of Science, GITAM University, Visakhapatnam, Andhra Pradesh, 530045, India.
¹¹ School of Life Sciences, Glocal University, Mirzapur Pole, Saharanpur, Uttar Pradesh, India.
¹² Departamento de Nutrición y Bioquímica, Facultad de Ciencias, Pontificia Universidad Javeriana, Bogotá, DC, Colombia. gesbarreto@gmail.com.
¹³ Instituto de Ciencias Biomédicas, Universidad Autónoma de Chile, Santiago, Chile. gesbarreto@gmail.com.
¹⁴ King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia. ashraf.gm@gmail.com.

PMID: 30338485
DOI: 10.1007/s12035-018-1397-x

Review

Role of GTPases in the Regulation of Mitochondrial Dynamics in Alzheimer's Disease and CNS-Related Disorders

Athanasios Alexiou et al. Mol Neurobiol. 2019 Jun.

. 2019 Jun;56(6):4530-4538.

doi: 10.1007/s12035-018-1397-x. Epub 2018 Oct 18.

Authors

Affiliations

¹ Novel Global Community Educational Foundation, Hebersham, Australia. alexiou@ngcef.net.
² AFNP Med Austria, Haidingergasse 29, 1030, Wien, Austria. alexiou@ngcef.net.
³ Medical School, Bioinformatics Program, University of Crete, Heraklion, Greece.
⁴ AFNP Med Austria, Haidingergasse 29, 1030, Wien, Austria.
⁵ Department of Informatics and Telecommunications, Bioinformatics Program, National and Kapodistrian University of Athens, Athens, Greece.
⁶ Department of Psychology, City Unity College of Athens, Athens, Greece.
⁷ Novel Global Community Educational Foundation, Hebersham, Australia.
⁸ King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia.
⁹ Enzymoics, 7 Peterlee Place, Hebersham, NSW, 2770, Australia.
¹⁰ Department of Biochemistry and Bioinformatics, Institute of Science, GITAM University, Visakhapatnam, Andhra Pradesh, 530045, India.
¹¹ School of Life Sciences, Glocal University, Mirzapur Pole, Saharanpur, Uttar Pradesh, India.
¹² Departamento de Nutrición y Bioquímica, Facultad de Ciencias, Pontificia Universidad Javeriana, Bogotá, DC, Colombia. gesbarreto@gmail.com.
¹³ Instituto de Ciencias Biomédicas, Universidad Autónoma de Chile, Santiago, Chile. gesbarreto@gmail.com.
¹⁴ King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia. ashraf.gm@gmail.com.

PMID: 30338485
DOI: 10.1007/s12035-018-1397-x

Abstract

Data obtained from several studies have shown that mitochondria are involved and play a central role in the progression of several distinct pathological conditions. Morphological alterations and disruptions on the functionality of mitochondria may be related to metabolic and energy deficiency in neurons in a neurodegenerative disorder. Several recent studies demonstrate the linkage between neurodegeneration and mitochondrial dynamics in the spectrum of a promising era called precision mitochondrial medicine. In this review paper, an analysis of the correlation between mitochondria, Alzheimer's disease, and other central nervous system (CNS)-related disorders like the Parkinson's disease and the autism spectrum disorder is under discussion. The role of GTPases like the mfn1, mfn2, opa1, and dlp1 in mitochondrial fission and fusion is also under investigation, influencing mitochondrial population and leading to oxidative stress and neuronal damage.

Keywords: Alzheimer’s disease; Mitochondria; Mitochondrial dynamics; Neurodegenerative diseases; Oxidative stress; Parkinson’s disease.

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References

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[1] Neuroreport. 2002 Oct 28;13(15):1989-93 - PubMed

[2] Neuroreport. 2002 Oct 28;13(15):1989-93 - PubMed

[3] Annu Rev Biochem. 2007;76:723-49 - PubMed

[4] Annu Rev Biochem. 2007;76:723-49 - PubMed

[5] Prog Neurobiol. 2016 Sep;144:5-26 - PubMed

[6] Prog Neurobiol. 2016 Sep;144:5-26 - PubMed

[7] Mol Neurobiol. 2018 Jul;55(7):5462-5477 - PubMed

[8] Mol Neurobiol. 2018 Jul;55(7):5462-5477 - PubMed

[9] Arch Neurol. 1985 Nov;42(11):1097-105 - PubMed

[10] Arch Neurol. 1985 Nov;42(11):1097-105 - PubMed

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Role of GTPases in the Regulation of Mitochondrial Dynamics in Alzheimer's Disease and CNS-Related Disorders

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Role of GTPases in the Regulation of Mitochondrial Dynamics in Alzheimer's Disease and CNS-Related Disorders

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