Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2018 Dec;46(12):4920-4929.
doi: 10.1177/0300060518804375. Epub 2018 Oct 17.

Positron emission tomography/computed tomography in the diagnosis, staging, and prognostic evaluation of natural killer/T-cell lymphoma

Jian-Jun Ding  1   2 , Ya-Lian Chen  1 , Shui-Hong Zhou  1 , Kui Zhao  3
Affiliations
Review

Positron emission tomography/computed tomography in the diagnosis, staging, and prognostic evaluation of natural killer/T-cell lymphoma

Jian-Jun Ding et al. J Int Med Res. 2018 Dec.

Abstract

Natural killer/T-cell lymphoma (NKTL) is a rare subtype of non-Hodgkin's lymphoma that is associated with Epstein-Barr virus infection. The clinicopathological features of NKTL are unique among lymphomas. NKTL is an aggressive disease with a poor prognosis in the absence of effective treatment. Accurate diagnosis and staging are essential to ensure an appropriate treatment strategy and accurate prognosis of NKTL. 18F-Fluorodexoyglucose-positron emission tomography/computed tomography (18F-FDG PET/CT) is a valuable technique in the diagnosis, staging, and prognostic evaluation of various types of malignant tumors, including NKTL. PET/CT imaging studies of patients with NKTL have shown that NKTL is 18F-FDG-avid and that PET/CT is superior to conventional methods in detecting cutaneous and extracutaneous lesions. We herein review recent PET/CT studies that have provided considerable insight into the diagnosis, staging, prognostic evaluation, and treatment effectiveness in patients with NKTL.

Keywords: 18F-fluorodexoyglucose-positron emission tomography/computed tomography; Natural killer/T-cell lymphoma; diagnosis; non-Hodgkin’s lymphoma; prognosis; staging.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. Cai Q, Luo X, Zhang G, et al. New prognostic model for extranodal natural killer/T cell lymphoma, nasal type. Ann Hematol 2014; 93: 1541–1549. doi:10.1007/s00277-014-2089-x. - PubMed
    1. William BM, Armitage JO. International analysis of the frequency and outcomes of NK/T-cell lymphomas. Best Pract Res Clin Haematol 2013; 26: 23–32. doi:10.1016/j.beha.2013.04.003. - PubMed
    1. Abouyabis AN, Shenoy PJ, Lechowicz MJ, et al. Incidence and outcomes of the peripheral T-cell lymphoma subtypes in the United States. Leuk Lymphoma 2008; 49: 2099–2107. doi:10.1080/10428190802455867. - PubMed
    1. Gill H, Liang RH, Tse E. Extranodal natural-killer/t-cell lymphoma, nasal type. Adv Hematol 2010; 2010: 627401. doi:10.1155/2010/627401. - PMC - PubMed
    1. Tse E, Kwong YL. Practical management of natural killer/T-cell lymphoma. Curr Opin Oncol 2012; 24: 480–486. doi:10.1097/CCO.0b013e3283556142. - PubMed

MeSH terms

LinkOut - more resources