Tumour microenvironment and metabolic plasticity in cancer and cancer stem cells: Perspectives on metabolic and immune regulatory signatures in chemoresistant ovarian cancer stem cells

doi:10.1016/j.semcancer.2018.10.002

Review

. 2018 Dec:53:265-281.

doi: 10.1016/j.semcancer.2018.10.002. Epub 2018 Oct 11.

Tumour microenvironment and metabolic plasticity in cancer and cancer stem cells: Perspectives on metabolic and immune regulatory signatures in chemoresistant ovarian cancer stem cells

Nuzhat Ahmed¹, Ruth Escalona², Dilys Leung³, Emily Chan⁴, George Kannourakis⁵

Affiliations

¹ Fiona Elsey Cancer Research Institute, Ballarat, Victoria, 3353, Australia; Federation University Australia, Ballarat, Victoria, 3010, Australia; The Hudson Institute of Medical Research, Victoria, 3168, Australia; Department of Obstetrics and Gynaecology, University of Melbourne, Victoria, 3052, Australia. Electronic address: nuzhata@unimelb.edu.au.
² Fiona Elsey Cancer Research Institute, Ballarat, Victoria, 3353, Australia; The Hudson Institute of Medical Research, Victoria, 3168, Australia; Department of Obstetrics and Gynaecology, University of Melbourne, Victoria, 3052, Australia.
³ Fiona Elsey Cancer Research Institute, Ballarat, Victoria, 3353, Australia.
⁴ Department of Obstetrics and Gynaecology, University of Melbourne, Victoria, 3052, Australia.
⁵ Fiona Elsey Cancer Research Institute, Ballarat, Victoria, 3353, Australia; Federation University Australia, Ballarat, Victoria, 3010, Australia.

PMID: 30317036
DOI: 10.1016/j.semcancer.2018.10.002

Free article

Review

Tumour microenvironment and metabolic plasticity in cancer and cancer stem cells: Perspectives on metabolic and immune regulatory signatures in chemoresistant ovarian cancer stem cells

Nuzhat Ahmed et al. Semin Cancer Biol. 2018 Dec.

Free article

. 2018 Dec:53:265-281.

doi: 10.1016/j.semcancer.2018.10.002. Epub 2018 Oct 11.

Authors

Nuzhat Ahmed¹, Ruth Escalona², Dilys Leung³, Emily Chan⁴, George Kannourakis⁵

Affiliations

¹ Fiona Elsey Cancer Research Institute, Ballarat, Victoria, 3353, Australia; Federation University Australia, Ballarat, Victoria, 3010, Australia; The Hudson Institute of Medical Research, Victoria, 3168, Australia; Department of Obstetrics and Gynaecology, University of Melbourne, Victoria, 3052, Australia. Electronic address: nuzhata@unimelb.edu.au.
² Fiona Elsey Cancer Research Institute, Ballarat, Victoria, 3353, Australia; The Hudson Institute of Medical Research, Victoria, 3168, Australia; Department of Obstetrics and Gynaecology, University of Melbourne, Victoria, 3052, Australia.
³ Fiona Elsey Cancer Research Institute, Ballarat, Victoria, 3353, Australia.
⁴ Department of Obstetrics and Gynaecology, University of Melbourne, Victoria, 3052, Australia.
⁵ Fiona Elsey Cancer Research Institute, Ballarat, Victoria, 3353, Australia; Federation University Australia, Ballarat, Victoria, 3010, Australia.

PMID: 30317036
DOI: 10.1016/j.semcancer.2018.10.002

Abstract

Cancer stem cells (CSCs) are a sub-population of tumour cells, which are responsible to drive tumour growth, metastasis and therapy resistance. It has recently been proposed that enhanced glucose metabolism and immune evasion by tumour cells are linked, and are modulated by the changing tumour microenvironment (TME) that creates a competition for nutrient consumption between tumour and different sub-types of cells attracted to the TME. To facilitate efficient nutrient distribution, oncogene-induced inflammatory milieu in the tumours facilitate adaptive metabolic changes in the surrounding non-malignant cells to secrete metabolites that are used as alternative nutrient sources by the tumours to sustain its increasing energy needs for growth and anabolic functions. This scenario also affects CSCs residing at the primary or metastatic niches. This review summarises recent advances in our understanding of the metabolic phenotypes of cancer cells and CSCs and how these processes are affected by the TME. We also discuss how the evolving TME modulates tumour cells and CSCs in cancer progression. Using previously described proteomic and genomic platforms, ovarian cancer cell lines and a mouse xenograft model we highlight the existence of metabolic and immune regulatory signatures in chemoresistant ovarian CSCs, and discuss how these processes may affect recurrence in ovarian tumours. We propose that progress in cancer control and eradication may depend not only on the elimination of highly chemoresistant CSCs, but also in designing novel strategies which would intervene with the tumour-promoting TME factors.

Keywords: Ascites; Cancer stem cells; Cancer-associated fibroblasts; Chemoresistance; Endothelial cells; Immune cells; Ovarian carcinoma; Tumour cells.

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Tumour microenvironment and metabolic plasticity in cancer and cancer stem cells: Perspectives on metabolic and immune regulatory signatures in chemoresistant ovarian cancer stem cells

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Tumour microenvironment and metabolic plasticity in cancer and cancer stem cells: Perspectives on metabolic and immune regulatory signatures in chemoresistant ovarian cancer stem cells

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