A review on injectable chitosan/beta glycerophosphate hydrogels for bone tissue regeneration

doi:10.1016/j.ijbiomac.2018.10.014

Review

. 2019 Jan:121:38-54.

doi: 10.1016/j.ijbiomac.2018.10.014. Epub 2018 Oct 4.

A review on injectable chitosan/beta glycerophosphate hydrogels for bone tissue regeneration

Sekaran Saravanan¹, Selvaraj Vimalraj², Palanisamy Thanikaivelan³, Sivanantham Banudevi⁴, Geetha Manivasagam⁵

Affiliations

¹ Centre for Nanotechnology & Advanced Biomaterials (CeNTAB), Department of Bioengineering, School of Chemical and Biotechnology, SASTRA University, Thanjavur 613 401, Tamil Nadu, India. Electronic address: saravanan@scbt.sastra.edu.
² Centre for Biotechnology, Anna University, Chennai 600 025, Tamil Nadu, India.
³ Advanced Materials Laboratory, Central Leather Research Institute (Council of Scientific and Industrial Research), Adyar, Chennai 600 020, India.
⁴ Centre for Nanotechnology & Advanced Biomaterials (CeNTAB), Department of Bioengineering, School of Chemical and Biotechnology, SASTRA University, Thanjavur 613 401, Tamil Nadu, India.
⁵ Centre for Biomaterials, Cellular and Molecular Theranostics, VIT University, Vellore, India.

PMID: 30291931
DOI: 10.1016/j.ijbiomac.2018.10.014

Review

A review on injectable chitosan/beta glycerophosphate hydrogels for bone tissue regeneration

Sekaran Saravanan et al. Int J Biol Macromol. 2019 Jan.

. 2019 Jan:121:38-54.

doi: 10.1016/j.ijbiomac.2018.10.014. Epub 2018 Oct 4.

Authors

Sekaran Saravanan¹, Selvaraj Vimalraj², Palanisamy Thanikaivelan³, Sivanantham Banudevi⁴, Geetha Manivasagam⁵

Affiliations

¹ Centre for Nanotechnology & Advanced Biomaterials (CeNTAB), Department of Bioengineering, School of Chemical and Biotechnology, SASTRA University, Thanjavur 613 401, Tamil Nadu, India. Electronic address: saravanan@scbt.sastra.edu.
² Centre for Biotechnology, Anna University, Chennai 600 025, Tamil Nadu, India.
³ Advanced Materials Laboratory, Central Leather Research Institute (Council of Scientific and Industrial Research), Adyar, Chennai 600 020, India.
⁴ Centre for Nanotechnology & Advanced Biomaterials (CeNTAB), Department of Bioengineering, School of Chemical and Biotechnology, SASTRA University, Thanjavur 613 401, Tamil Nadu, India.
⁵ Centre for Biomaterials, Cellular and Molecular Theranostics, VIT University, Vellore, India.

PMID: 30291931
DOI: 10.1016/j.ijbiomac.2018.10.014

Abstract

Tissue engineering (TE) is a promising approach for repairing diseased and damaged bone tissue. Injectable hydrogel based strategies offer a wide range of applications in rapid recovery of bone defects by acting as filler materials and depots for delivering various bioactive molecules and averting the need for surgical intervention. Chitosan (CS), a natural polysaccharide, forms a thermosensitive injectable hydrogel through the addition of beta-glycerophosphate (β-GP). This hybrid hydrogel possesses numerous advantages namely mimicking native extracellular matrix (ECM) and providing an amenable microenvironment for cell growth. In this review, a brief insight into the gelation mechanism of CS/GP hydrogels, modifications, bioactive additives and their applications in treating bone defects are presented.

Keywords: Beta-glycerophosphate; Bone; Chitosan; Thermoresponsive hydrogel; Tissue engineering.

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A review on injectable chitosan/beta glycerophosphate hydrogels for bone tissue regeneration

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A review on injectable chitosan/beta glycerophosphate hydrogels for bone tissue regeneration

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