Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2018 Sep 22;4(9):e00816.
doi: 10.1016/j.heliyon.2018.e00816. eCollection 2018 Sep.

Effectiveness of corticosteroid in the treatment of dengue - A systemic review

S M Rathnasiri Bandara  1 , H M M T B Herath  2
Affiliations
Review

Effectiveness of corticosteroid in the treatment of dengue - A systemic review

S M Rathnasiri Bandara et al. Heliyon. .

Abstract

Corticosteroids are used therapeutically for a broad spectrum of diseases including autoimmune, allergic and inflammatory diseases. However in trials, the evidence for using corticosteroids in dengue is inconclusive and the quality of evidence is low. This systemic review is conducted to review clinical trials on dengue and steroid therapy to identify the current strength and weakness of evidence for the use of corticosteroids. We searched MEDLINE/PUBMED and Google scholar for publications on steroid use in dengue and the relevant authors of the study were contacted for additional information, as required. This review includes thirteen studies enrolling 1293 children and adult participants. There was no evidence of viremia and no significant side effects after the administration of low and high doses of oral corticosteroids and high doses of intravenous corticosteroids. Beneficial therapeutic effects were seen in some studies, which used high doses or multiple doses of steroids. The effectiveness of corticosteroids in dengue is depended upon sustained therapeutic blood levels of corticosteroids for an adequate duration and using a steroid with higher receptor affinity. Further clinical trials using pharmacologically and immunologically accepted standard steroid protocols are warranted to validate this conclusion.

Keywords: Evidence-based medicine; Infectious disease; Internal medicine.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Alangari A.A. Corticosteroids in the treatment of acute asthma. Ann. Thorac. Med. 2014;9(4):187–192. - PMC - PubMed
    1. Alpdogan O., Budak-Alpdogan T., Ratip S., Firatli-Tuglular T., Tanriverdi S. Efficacy of high-dose methylprednisolone as a first-line therapy in adult patients with idiopathic thrombocytopenic purpura. Br. J. Haematol. 1998;103(4):1061–1063. - PubMed
    1. Ansari M.T., Tsertsvadze A., Moher D. Grading quality of evidence and strength of recommendations: a perspective. PLoS Med. 2009;6(9) - PMC - PubMed
    1. Badsha H., Edwards C.J. Intravenous pulses of methylprednisolone for systemic lupus erythematosus. Semin. Arthritis Rheum. 2003;32(6):370–377. - PubMed
    1. Berkovich R. Treatment of acute relapses in multiple sclerosis. Expert Rev. Neurother. 2013;10(1):97–105. - PMC - PubMed

LinkOut - more resources