Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1986 Apr;6(4):1276-82.
doi: 10.1128/mcb.6.4.1276-1282.1986.

Diverse long terminal repeats are associated with murine retroviruslike (VL30) elements

A Itin, E Keshet

Diverse long terminal repeats are associated with murine retroviruslike (VL30) elements

A Itin et al. Mol Cell Biol. 1986 Apr.

Abstract

The VL30 family is a retroviruslike gene family with no apparent nucleic acid homology to any known retrovirus. Over 100 copies of VL30 DNA elements are dispersed throughout the mouse genome. Sequence analysis of the VL30 long terminal repeat (LTR) units showed that, whereas the LTR units of a given VL30 DNA element were almost identical, the LTR units associated with distinct members of the family were very different from one another. Comparison of the LTR sequences possessed by two particular VL30 DNA elements revealed a pattern of extensively homologous DNA segments adjacent to only distantly related DNA sequences. With the aid of sub-LTR probes, it was shown that a certain LTR is composed of both U5 sequences that are abundantly present in all species of the genus Mus and a U3 region detected only in Mus musculus. In addition, we isolated a VL30 DNA element in which the LTR units were replaced by the LTR units of an apparently novel retroviruslike family. These findings suggest that recombinations have played a role in generating the diverse population of VL30-associated LTRs.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Cell. 1977 Dec;12(4):963-72 - PubMed
    1. Cell. 1985 Mar;40(3):491-500 - PubMed
    1. Curr Top Microbiol Immunol. 1978;79:295-309 - PubMed
    1. J Virol. 1978 May;26(2):257-64 - PubMed
    1. J Gen Virol. 1979 Jan;42(1):1-26 - PubMed

Publication types

LinkOut - more resources