Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 1986:31:1-51.
doi: 10.1016/s0065-3527(08)60261-4.

Ambisense RNA genomes of arenaviruses and phleboviruses

D H Bishop
Review

Ambisense RNA genomes of arenaviruses and phleboviruses

D H Bishop. Adv Virus Res. 1986.

Abstract

This chapter reviews the evidence that shows that arenaviruses and members of one genus of the Bunyaviridae (phleboviruses) have some proteins coded in subgenomic, viral-sense mRNA species and other proteins coded in subgenomic, viral-complementary mRNA sequences. This unique feature is discussed in relation to the implications it has on the intracellular infection process and how such a coding arrangement may have evolved. The chapter presents a list of the known members of the arenaviridae, their origins, and the vertebrate hosts from which isolates have been reported. It discusses the structural components, the infection cycle, and genetic attributes of arenaviruses. In order to determine how arenaviruses code for gene products, the S RNA species of Pichinde virus and that of a viscerotropic strain of LCM virus (LCM-WE) have been cloned into DNA and sequenced. The arenavirus S RNA is described as having an ambisense strategy, to denote the fact that both viral and viral-complementary sequences are used to make gene products. The chapter discusses the infection cycle, the structural and genetic properties of bunyaviridae member.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Abelson H.T., Smith G.H., Hoffman H.A., Rowe W.P. J. Natl. Cancer Inst. 1969;42:497–515. - PubMed
    1. Akashi H., Bishop D.H.L. J. Virol. 1983;45:1155–1158. - PMC - PubMed
    1. Akashi H., Gay M., Ihara T., Bishop D.H.L. Virus Res. 1984;1:51–63. - PubMed
    1. Anon M.C., Grau O., Martinez Segovia Z., Franze-Fernandez M.T. J. Virol. 1976;18:833–838. - PMC - PubMed
    1. Armstrong C., Lillie R.D. Public Health Rep. 1934;49:1019–1027.

LinkOut - more resources