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Review
. 1986 Oct 10;234(4773):161-6.
doi: 10.1126/science.3018928.

Early signals in the mitogenic response

Review

Early signals in the mitogenic response

E Rozengurt. Science. .

Abstract

Polypeptide growth factors, regulatory peptides, and a variety of pharmacological agents acting alone or synergistically induce mitogenesis in cultured fibroblasts. The early signals in the membrane, cytosol, and nucleus promoted by these extracellular factors, together with their mitogenic effectiveness, are integrated in a unified hypothesis for the regulation of fibroblast growth.

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