Viral infection and atherosclerosis

doi:10.1007/s10096-018-3370-z

Review

. 2018 Dec;37(12):2225-2233.

doi: 10.1007/s10096-018-3370-z. Epub 2018 Sep 5.

Viral infection and atherosclerosis

Nima Hemmat^{1

2}, Amin Ebadi^{1

2}, Reza Badalzadeh^{3

4}, Mohammad Yousef Memar^{2

5}, Hossein Bannazadeh Baghi^{6

7

8}

Affiliations

¹ Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
² Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, PO Box 5165665931, Tabriz, Iran.
³ Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
⁴ Department of Physiology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
⁵ Department of Microbiology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
⁶ Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. hbannazadeh@tbzmed.ac.ir.
⁷ Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, PO Box 5165665931, Tabriz, Iran. hbannazadeh@tbzmed.ac.ir.
⁸ Department of Microbiology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran. hbannazadeh@tbzmed.ac.ir.

PMID: 30187247
DOI: 10.1007/s10096-018-3370-z

Review

Viral infection and atherosclerosis

Nima Hemmat et al. Eur J Clin Microbiol Infect Dis. 2018 Dec.

. 2018 Dec;37(12):2225-2233.

doi: 10.1007/s10096-018-3370-z. Epub 2018 Sep 5.

Authors

Nima Hemmat^{1

2}, Amin Ebadi^{1

2}, Reza Badalzadeh^{3

4}, Mohammad Yousef Memar^{2

5}, Hossein Bannazadeh Baghi^{6

7

8}

Affiliations

¹ Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
² Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, PO Box 5165665931, Tabriz, Iran.
³ Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
⁴ Department of Physiology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
⁵ Department of Microbiology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
⁶ Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. hbannazadeh@tbzmed.ac.ir.
⁷ Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, PO Box 5165665931, Tabriz, Iran. hbannazadeh@tbzmed.ac.ir.
⁸ Department of Microbiology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran. hbannazadeh@tbzmed.ac.ir.

PMID: 30187247
DOI: 10.1007/s10096-018-3370-z

Abstract

Several risk factors have been described for the pathogenesis of atherosclerosis. Infectious diseases are suggested to be a causative factor, and some viruses have been studied for their relation with atherosclerotic diseases. Studies report two hypotheses, direct and indirect effects, for the role of viral infections in atherogenesis. Viruses are able to initiate atherosclerosis by two different pathways. They can exert their direct effects on atherogenesis by infecting vascular cells and then inducing inflammation in the endothelium and smooth muscle cells. Alternatively, they can also apply indirect effects by infecting non-vascular cells and inducing systemic inflammation. In this review, we consider the available data about the effects and correlations of DNA and RNA viruses on atherosclerosis.

Keywords: Atherosclerosis; Inflammation; Viral infection.

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[1] Indian J Med Sci. 2007 Dec;61(12):648-55 - PubMed

[2] Indian J Med Sci. 2007 Dec;61(12):648-55 - PubMed

[3] Intervirology. 2014;57(6):365-8 - PubMed

[4] Intervirology. 2014;57(6):365-8 - PubMed

[5] Circulation. 2000 Dec 19;102(25):3039-45 - PubMed

[6] Circulation. 2000 Dec 19;102(25):3039-45 - PubMed

[7] J Infect Dis. 2001 Jan 15;183(2):226-231 - PubMed

[8] J Infect Dis. 2001 Jan 15;183(2):226-231 - PubMed

[9] PLoS One. 2007 May 30;2(5):e473 - PubMed

[10] PLoS One. 2007 May 30;2(5):e473 - PubMed

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Viral infection and atherosclerosis

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Viral infection and atherosclerosis

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