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. 1986 Apr 15;235(2):621-4.
doi: 10.1042/bj2350621.

Target size of the adenosine Ri receptor

L T Frame, S M Yeung, J C Venter, D M Cooper

Target size of the adenosine Ri receptor

L T Frame et al. Biochem J. .

Abstract

The adenosine receptor of rat cerebral-cortical membranes was examined by radiation inactivation. In control membranes the receptor is distributed between high- and low-affinity states, that can be preferentially expressed by Mg2+ ions and guanine nucleotides respectively. Upon exposure to increasing doses of radiation, the high-affinity receptor decayed linearly as a function of radiation dose. This decay rate corresponded to a target size of 63,000 Da, when compared with the decay of the muscarinic cholinergic receptor that was also measured in these membranes.

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