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Review
. 2019 Jul:91:86-93.
doi: 10.1016/j.semcdb.2018.08.016. Epub 2018 Sep 1.

Turning mesoderm into kidney

Alan J Davidson  1 , Paula Lewis  2 , Aneta Przepiorski  2 , Veronika Sander  2
Affiliations
Review

Turning mesoderm into kidney

Alan J Davidson et al. Semin Cell Dev Biol. 2019 Jul.

Abstract

The intermediate mesoderm is located between the somites and the lateral plate mesoderm and gives rise to renal progenitors that contribute to the three mammalian kidney types (pronephros, mesonephros and metanephros). In this review, focusing largely on murine kidney development, we examine how the intermediate mesoderm forms during gastrulation/axis elongation and how it progressively gives rise to distinct renal progenitors along the rostro-caudal axis. We highlight some of the potential signalling cues and core transcription factor circuits that direct these processes, up to the point of early metanephric kidney formation.

Keywords: Embryo; Embryonic development; Gastrulation; Intermediate mesoderm; Kidney; Mesoderm; Metanephros; Nephron progenitor.

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