Delineating Pro-Angiogenic Myeloid Cells in Cancer Therapy

doi:10.3390/ijms19092565

Review

. 2018 Aug 29;19(9):2565.

doi: 10.3390/ijms19092565.

Delineating Pro-Angiogenic Myeloid Cells in Cancer Therapy

Benjamin W Johnson¹, Bhagelu R Achyut², Sadanand Fulzele³, Ashis K Mondal⁴, Ravindra Kolhe⁵, Ali S Arbab⁶

Affiliations

¹ Department of Pathology, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA. bejohnson1@augusta.edu.
² Cancer Animal Models Shared Resource, Winship Cancer Center of Emory University, Atlanta, GA 30322, USA. bhagelu.r.achyut@emory.edu.
³ Department of Orthopedics, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA. sfulzele@augusta.edu.
⁴ Department of Pathology, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA. amondal@augusta.edu.
⁵ Department of Pathology, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA. rkolhe@augusta.edu.
⁶ Tumor Angiogenesis Laboratory, Georgia Cancer Center, Augusta University, Augusta, GA 30912, USA. aarbab@augusta.edu.

PMID: 30158456
PMCID: PMC6165286
DOI: 10.3390/ijms19092565

Review

Delineating Pro-Angiogenic Myeloid Cells in Cancer Therapy

Benjamin W Johnson et al. Int J Mol Sci. 2018.

. 2018 Aug 29;19(9):2565.

doi: 10.3390/ijms19092565.

Authors

Benjamin W Johnson¹, Bhagelu R Achyut², Sadanand Fulzele³, Ashis K Mondal⁴, Ravindra Kolhe⁵, Ali S Arbab⁶

Affiliations

¹ Department of Pathology, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA. bejohnson1@augusta.edu.
² Cancer Animal Models Shared Resource, Winship Cancer Center of Emory University, Atlanta, GA 30322, USA. bhagelu.r.achyut@emory.edu.
³ Department of Orthopedics, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA. sfulzele@augusta.edu.
⁴ Department of Pathology, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA. amondal@augusta.edu.
⁵ Department of Pathology, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA. rkolhe@augusta.edu.
⁶ Tumor Angiogenesis Laboratory, Georgia Cancer Center, Augusta University, Augusta, GA 30912, USA. aarbab@augusta.edu.

PMID: 30158456
PMCID: PMC6165286
DOI: 10.3390/ijms19092565

Abstract

Recent evidence suggests that myeloid cells are critical in cancer development and therapy resistance processes. Pharmacological targeting of tumor-associated myeloid cells is an emerging approach among upcoming immune therapies. Surprisingly, myeloid cells are heterogeneous, including a subset of the myeloid cell displaying angiogenic properties in solid tumors. There is an urgent need to delineate angiogenic myeloid cell populations in order to facilitate specific targeting of protumor myeloid cells among heterogeneous pool. This review article is intended to compile all the relevant information in the literature for improved understanding of angiogenic myeloid cells and their role in tumor refractoriness to cancer therapy.

Keywords: MDSC; angiogenic; antiangiogenic; chemotherapy; immunotherapy; myeloid; radiotherapy; tumor.

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Conflict of interest statement

The authors declare no conflict of interest.

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References

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[1] Gabrilovich D.I., Ostrand-Rosenberg S., Bronte V. Coordinated regulation of myeloid cells by tumors. Nat. Rev. Immunol. 2012;12:253–268. doi: 10.1038/nri3175. - DOI - PMC - PubMed

[2] Gabrilovich D.I., Ostrand-Rosenberg S., Bronte V. Coordinated regulation of myeloid cells by tumors. Nat. Rev. Immunol. 2012;12:253–268. doi: 10.1038/nri3175. - DOI - PMC - PubMed

[3] Gabrilovich D.I. Myeloid-derived suppressor cells. Cancer Immunol Res. 2017;5:3–8. doi: 10.1158/2326-6066.CIR-16-0297. - DOI - PMC - PubMed

[4] Gabrilovich D.I. Myeloid-derived suppressor cells. Cancer Immunol Res. 2017;5:3–8. doi: 10.1158/2326-6066.CIR-16-0297. - DOI - PMC - PubMed

[5] Bronte V., Brandau S., Chen S.-H., Colombo M.P., Frey A.B., Greten T.F., Mandruzzato S., Murray P.J., Ochoa A., Ostrand-Rosenberg S., et al. Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards. Nat. Commun. 2016 doi: 10.1038/ncomms12150. - DOI - PMC - PubMed

[6] Bronte V., Brandau S., Chen S.-H., Colombo M.P., Frey A.B., Greten T.F., Mandruzzato S., Murray P.J., Ochoa A., Ostrand-Rosenberg S., et al. Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards. Nat. Commun. 2016 doi: 10.1038/ncomms12150. - DOI - PMC - PubMed

[7] Kiss M., van Gassen S., Movahedi K., Saeys Y., Damya L. Myeloid Cell Heterogeneity in Cancer: Not a single cell alike. Cell. Immunol. 2018 doi: 10.1016/j.cellimm.2018.02.008. - DOI - PubMed

[8] Kiss M., van Gassen S., Movahedi K., Saeys Y., Damya L. Myeloid Cell Heterogeneity in Cancer: Not a single cell alike. Cell. Immunol. 2018 doi: 10.1016/j.cellimm.2018.02.008. - DOI - PubMed

[9] Xu C., Bailly-Maitre B., Reed J.C. Endoplasmic reticulum stress: Cell life and death decisions. J. Clin. Investig. 2005;115:2656–2664. doi: 10.1172/JCI26373. - DOI - PMC - PubMed

[10] Xu C., Bailly-Maitre B., Reed J.C. Endoplasmic reticulum stress: Cell life and death decisions. J. Clin. Investig. 2005;115:2656–2664. doi: 10.1172/JCI26373. - DOI - PMC - PubMed

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Delineating Pro-Angiogenic Myeloid Cells in Cancer Therapy

Affiliations

Delineating Pro-Angiogenic Myeloid Cells in Cancer Therapy

Authors

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Abstract

Conflict of interest statement

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