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Review
. 2018 Jul 15:2018:3170801.
doi: 10.1155/2018/3170801. eCollection 2018.

Inner Ear Hair Cell Protection in Mammals against the Noise-Induced Cochlear Damage

Muhammad Waqas  1   2 , Song Gao  3 , Iram-Us-Salam  1 , Muhammad Kazim Ali  1   4 , Yongming Ma  3 , Wenyan Li  5
Affiliations
Review

Inner Ear Hair Cell Protection in Mammals against the Noise-Induced Cochlear Damage

Muhammad Waqas et al. Neural Plast. .

Abstract

Inner ear hair cells are mechanosensory receptors that perceive mechanical sound and help to decode the sound in order to understand spoken language. Exposure to intense noise may result in the damage to the inner ear hair cells, causing noise-induced hearing loss (NIHL). Particularly, the outer hair cells are the first and the most affected cells in NIHL. After acoustic trauma, hair cells lose their structural integrity and initiate a self-deterioration process due to the oxidative stress. The activation of different cellular death pathways leads to complete hair cell death. This review specifically presents the current understanding of the mechanism exists behind the loss of inner ear hair cell in the auditory portion after noise-induced trauma. The article also explains the recent hair cell protection strategies to prevent the damage and restore hearing function in mammals.

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Figure 1
Figure 1
Schematic of the generation of reactive oxygen species (ROS) along with the activation of caspase-mediated and independent death pathways in hair cell after noise-induced oxidative stress.
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