doi: 10.1126/science.3010456.
Trans-activator gene of HTLV-II induces IL-2 receptor and IL-2 cellular gene expression
- PMID: 3010456
- DOI: 10.1126/science.3010456
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Trans-activator gene of HTLV-II induces IL-2 receptor and IL-2 cellular gene expression
Science.
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Abstract
The human T-lymphotropic viruses types I and II (HTLV-I and -II) have been etiologically linked with certain T-cell leukemias and lymphomas that characteristically display membrane receptors for interleukin-2. The relation of these viruses to this growth factor receptor has remained unexplained. It is demonstrated here that introduction of the trans-activator (tat) gene of HTLV-II into the Jurkat T-lymphoid cell line results in the induction of both interleukin-2 receptor and interleukin-2 gene expression. The coexpression of these cellular genes may play a role in the altering T-cell growth following retroviral infection.
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