When Hepatitis B Virus Meets Interferons
- PMID: 30072974
- PMCID: PMC6058040
- DOI: 10.3389/fmicb.2018.01611
When Hepatitis B Virus Meets Interferons
Abstract
Chronic hepatitis B virus (HBV) infection imposes a severe burden on global public health. Currently, there are no curative therapies for millions of chronic HBV-infected patients (Lok et al., 2017). Interferon (IFN; including pegylated IFN) is an approved anti-HBV drug that not only exerts direct antiviral activity, but also augments immunity against HBV infection. Through a systematic review of the literature, here we summarize and present recent progress in research regarding the interactions between IFN and HBV as well as dissect the antiviral mechanisms of IFN. We focus on inhibition of HBV replication by IFN-stimulated genes (ISGs) as well as inhibition of IFN signaling by HBV and viral proteins. Finally, we briefly discuss current IFN-based HBV treatment strategies. This review may help to better understand the mechanisms involved in the therapeutic action of IFN as well as the crosstalk between IFN and HBV, and facilitate the development of both direct-acting and immunology-based new HBV drugs.
Keywords: HBV; HBV drug; ISGs; TRIMs; cccDNA; interferon.
Figures




Similar articles
-
Intracellular interferon signalling pathways as potential regulators of covalently closed circular DNA in the treatment of chronic hepatitis B.World J Gastroenterol. 2021 Apr 14;27(14):1369-1391. doi: 10.3748/wjg.v27.i14.1369. World J Gastroenterol. 2021. PMID: 33911462 Free PMC article. Review.
-
HDV RNA replication is associated with HBV repression and interferon-stimulated genes induction in super-infected hepatocytes.Antiviral Res. 2016 Dec;136:19-31. doi: 10.1016/j.antiviral.2016.10.006. Epub 2016 Oct 19. Antiviral Res. 2016. PMID: 27771387
-
Interferon-inducible MX2 is a host restriction factor of hepatitis B virus replication.J Hepatol. 2020 May;72(5):865-876. doi: 10.1016/j.jhep.2019.12.009. Epub 2019 Dec 18. J Hepatol. 2020. PMID: 31863794
-
Latest developments in the treatment of hepatitis B.Minerva Gastroenterol Dietol. 2016 Mar;62(1):88-102. Epub 2015 Oct 8. Minerva Gastroenterol Dietol. 2016. PMID: 26448309 Review.
-
Development of a Novel Site-Specific Pegylated Interferon Beta for Antiviral Therapy of Chronic Hepatitis B Virus.Antimicrob Agents Chemother. 2017 May 24;61(6):e00183-17. doi: 10.1128/AAC.00183-17. Print 2017 Jun. Antimicrob Agents Chemother. 2017. PMID: 28373196 Free PMC article.
Cited by
-
Suppression of Interferon-α Treatment Response by Host Negative Factors in Hepatitis B Virus Infection.Front Med (Lausanne). 2021 Nov 24;8:784172. doi: 10.3389/fmed.2021.784172. eCollection 2021. Front Med (Lausanne). 2021. PMID: 34901094 Free PMC article. Review.
-
HBV/HIV Coinfection: Impact on the Development and Clinical Treatment of Liver Diseases.Front Med (Lausanne). 2021 Oct 4;8:713981. doi: 10.3389/fmed.2021.713981. eCollection 2021. Front Med (Lausanne). 2021. PMID: 34676223 Free PMC article. Review.
-
Methylation profile of hepatitis B virus is not influenced by interferon α in human liver cancer cells.Mol Med Rep. 2021 Oct;24(4):715. doi: 10.3892/mmr.2021.12354. Epub 2021 Aug 13. Mol Med Rep. 2021. PMID: 34396432 Free PMC article.
-
The Spliceosome Factor EFTUD2 Promotes IFN Anti-HBV Effect through mRNA Splicing.Mediators Inflamm. 2023 Jun 23;2023:2546278. doi: 10.1155/2023/2546278. eCollection 2023. Mediators Inflamm. 2023. PMID: 37396299 Free PMC article.
-
When does hepatitis B virus meet long-stranded noncoding RNAs?Front Microbiol. 2022 Sep 2;13:962186. doi: 10.3389/fmicb.2022.962186. eCollection 2022. Front Microbiol. 2022. PMID: 36118202 Free PMC article. Review.
References
-
- Belloni L., Allweiss L., Guerrieri F., Pediconi N., Volz T., Pollicino T., et al. (2012). IFN-alpha inhibits HBV transcription and replication in cell culture and in humanized mice by targeting the epigenetic regulation of the nuclear cccDNA minichromosome. J. Clin. Invest. 122 529–537. 10.1172/JCI58847 - DOI - PMC - PubMed
Publication types
LinkOut - more resources
Full Text Sources
Other Literature Sources