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Review
. 2018 Oct;34(2):153-180.
doi: 10.1080/02648725.2018.1471566. Epub 2018 Aug 3.

Long noncoding RNAs: regulation, function and cancer

Aras Rafiee  1 , Farhad Riazi-Rad  2 , Mohammad Havaskary  3 , Fatemeh Nuri  4
Affiliations
Review

Long noncoding RNAs: regulation, function and cancer

Aras Rafiee et al. Biotechnol Genet Eng Rev. 2018 Oct.

Abstract

Long noncoding RNAs (lncRNAs) are non-protein-coding RNA transcripts that exert a key role in many cellular processes and have potential toward addressing disease etiology. Here, we review existing noncoding RNA classes and then describe a variety of mechanisms and functions by which lncRNAs regulate gene expression such as chromatin remodeling, genomic imprinting, gene transcription and post-transcriptional processing. We also examine several lncRNAs that contribute significantly to pathogenesis, oncogenesis, tumor suppression and cell cycle arrest of diverse cancer types and also give a summary of the pathways that lncRNAs might be involved in.

Keywords: LncRNA; cancer; gene regulation; molecular mechanism.

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