Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2018 Jul;13(7):1156-1158.
doi: 10.4103/1673-5374.235020.

What can computational modeling offer for studying the Ca2+ dysregulation in Alzheimer's disease: current research and future directions

Jingyi Liang  1 , Don Kulasiri  1
Affiliations
Review

What can computational modeling offer for studying the Ca2+ dysregulation in Alzheimer's disease: current research and future directions

Jingyi Liang et al. Neural Regen Res. 2018 Jul.

Abstract

Ca2+ dysregulation is an early event observed in Alzheimer's disease (AD) patients preceding the presence of its clinical symptoms. Dysregulation of neuronal Ca2+ will cause synaptic loss and neuronal death, eventually leading to memory impairments and cognitive decline. Treatments targeting Ca2+ signaling pathways are potential therapeutic strategies against AD. The complicated interactions make it challenging and expensive to study the underlying mechanisms as to how Ca2+ signaling contributes to the pathogenesis of AD. Computational modeling offers new opportunities to study the signaling pathway and test proposed mechanisms. In this mini-review, we present some computational approaches that have been used to study Ca2+ dysregulation of AD by simulating Ca2+ signaling at various levels. We also pointed out the future directions that computational modeling can be done in studying the Ca2+ dysregulation in AD.

Keywords: Alzheimer's disease; Ca2+ dysregulation; Ca2+ hypothesis; amyloid-beta; computational modeling; computational neuroscience.

PubMed Disclaimer

Conflict of interest statement

None

Similar articles

See all similar articles

References

    1. Alzheimer’s Association 2017 Alzheimer’s disease facts and figures. Alzheimers Dement. 2017;13:325–373.
    1. Berridge MJ. Calcium hypothesis of Alzheimer’s disease. Pflugers Arch. 2010;459:441–449. - PubMed
    1. Bezprozvanny I, Mattson MP. Neuronal calcium mishandling and the pathogenesis of Alzheimer’s disease. Trends Neurosci. 2008;31:454–463. - PMC - PubMed
    1. Blackwell KT. Approaches and tools for modeling signaling pathways and calcium dynamics in neurons. J Neurosci Methods. 2013;220:131–140. - PMC - PubMed
    1. Brette R, Rudolph M, Carnevale T, Hines M, Beeman D, Bower JM, Diesmann M, Morrison A, Goodman PH, Harris FC, Jr, Zirpe M, Natschläger T, Pecevski D, Ermentrout B, Djurfeldt M, Lansner A, Rochel O, Vieville T, Muller E, Davison AP, et al. Simulation of networks of spiking neurons: a review of tools and strategies. J Comput Neurosci. 2007;23:349–398. - PMC - PubMed