Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2018 Jun 19:2018:4579734.
doi: 10.1155/2018/4579734. eCollection 2018.

Chicken Is a Useful Model to Investigate the Role of Adipokines in Metabolic and Reproductive Diseases

Namya Mellouk  1 , Christelle Ramé  1 , Alix Barbe  1 , Jérémy Grandhaye  1 , Pascal Froment  1 , Joëlle Dupont  1
Affiliations
Review

Chicken Is a Useful Model to Investigate the Role of Adipokines in Metabolic and Reproductive Diseases

Namya Mellouk et al. Int J Endocrinol. .

Abstract

Reproduction is a complex and essential physiological process required by all species to produce a new generation. This process involves strict hormonal regulation, depending on a connection between the hypothalamus-pituitary-gonadal axis and peripheral organs. Metabolic homeostasis influences the reproductive functions, and its alteration leads to disturbances in the reproductive functions of humans as well as animals. For a long time, adipose tissue has been recognised as an endocrine organ but its ability to secrete and release hormones called adipokines is now emerging. Adipokines have been found to play a major role in the regulation of metabolic and reproductive processes at both central and peripheral levels. Leptin was initially the first adipokine that has been described to be the most involved in the metabolism/reproduction interrelation in mammals. In avian species, the role of leptin is still under debate. Recently, three novel adipokines have been discovered: adiponectin (ADIPOQ, ACRP30), visfatin (NAMPT, PBEF), and chemerin (RARRES2, TIG2). However, their mode of action between mammalian and nonmammalian species is different due to the different reproductive and metabolic systems. Herein, we will provide an overview of the structure and function related to metabolic and reproductive mechanisms of the latter three adipokines with emphasis on avian species.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Comparison of adiponectin (a), visfatin (b), and chemerin (c) effects on main metabolic functions in mammal versus chicken. nd: not determined; + correlated: positively correlated; − correlated: negatively correlated; ↑: increase; ↓: decrease.
Figure 2
Figure 2
Comparison of adiponectin, visfatin, and chemerin effects on female (a) and male (b) steroidogenesis in mammal (a, b) versus chicken (a). IGF1: insulin like growth factor 1, FSH: follicle-stimulating hormone, LH: luteinizing hormone, hCG: human chorionic gonadotropin.
Figure 3
Figure 3
Structure of chemerin (a) and representation of chemerin system signalling (b). CMKLR1 (chemokine-like receptor); GPR1 (G protein-coupled receptor 1); and CCRL2 (chemokine (C-C motif) receptor-like 2).
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Wozniak S. E., Gee L. L., Wachtel M. S., Frezza E. E. Adipose tissue: the new endocrine organ? A review article. Digestive Diseases and Sciences. 2009;54(9):1847–1856. doi: 10.1007/s10620-008-0585-3. - DOI - PubMed
    1. Waki H., Tontonoz P. Endocrine functions of adipose tissue. Annual Review of Pathology: Mechanisms of Disease. 2007;2(1):31–56. doi: 10.1146/annurev.pathol.2.010506.091859. - DOI - PubMed
    1. Ahima R. S., Flier J. S. Adipose tissue as an endocrine organ. Trends in Endocrinology & Metabolism. 2000;11(8):327–332. doi: 10.1016/S1043-2760(00)00301-5. - DOI - PubMed
    1. Zhang Y., Proenca R., Maffei M., Barone M., Leopold L., Friedman J. M. Positional cloning of the mouse obese gene and its human homologue. Nature. 1994;372(6505):425–432. doi: 10.1038/372425a0. - DOI - PubMed
    1. Haslam D. W., James W. P. T. Obesity. Lancet. 2005;366(9492):1197–1209. doi: 10.1016/S0140-6736(05)67483-1. - DOI - PubMed

LinkOut - more resources