A lncRNA-like Role for LINE1s in Development

doi:10.1016/j.devcel.2018.06.022

Comment

. 2018 Jul 16;46(2):132-134.

doi: 10.1016/j.devcel.2018.06.022.

A lncRNA-like Role for LINE1s in Development

Drew D Honson¹, Todd S Macfarlan²

Affiliations

¹ The Eunice Kennedy Shriver National Institute of Child Health and Human Development, The National Institutes of Health, Bethesda, MD 20892, USA.
² The Eunice Kennedy Shriver National Institute of Child Health and Human Development, The National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: todd.macfarlan@nih.gov.

PMID: 30016617
PMCID: PMC6309210
DOI: 10.1016/j.devcel.2018.06.022

Comment

A lncRNA-like Role for LINE1s in Development

Drew D Honson et al. Dev Cell. 2018.

. 2018 Jul 16;46(2):132-134.

doi: 10.1016/j.devcel.2018.06.022.

Authors

Drew D Honson¹, Todd S Macfarlan²

Affiliations

¹ The Eunice Kennedy Shriver National Institute of Child Health and Human Development, The National Institutes of Health, Bethesda, MD 20892, USA.
² The Eunice Kennedy Shriver National Institute of Child Health and Human Development, The National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: todd.macfarlan@nih.gov.

PMID: 30016617
PMCID: PMC6309210
DOI: 10.1016/j.devcel.2018.06.022

Abstract

Transposable elements (TEs) have profoundly affected the evolution of transcriptional and chromatin profiles in mammalian genomes. In a recent paper, Percharde et al. (2018) identify a lncRNA-like function for LINE1 transposable elements in regulating gene expression to facilitate embryonic stem cell self-renewal and preimplantation development.

Published by Elsevier Inc.

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Figures

**Figure 1.. LINE1 Depletion Experiments and Model for LINE1 lncRNA-like Function**
(A) Percharde et al. (2018) depleted LINE1 RNAin mouseembryonic stem cells(mESCs) and zygotes. Both ESCs and early embryos exhibited increased 2C-stage gene expression. ESCs displayed loss of selfrenewal, reduced rDNA transcription, and lower total RNA and nascent transcription. Zygotes exhibited lower chromosome accessibility and reduced zygotic genome activation. (B) The authors propose that LINE1 RNA binds Nucleolin and KAP1 and interacts with the genome at *Dux* and rDNA loci. At the *Dux* locus, the complex represses transcription, whereas at rDNA it promotes expression of rRNAand riboproteins, facilitating the self-renewal of ESCs and thetransition through early preimplantation development.

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Comment on

A LINE1-Nucleolin Partnership Regulates Early Development and ESC Identity.
Percharde M, Lin CJ, Yin Y, Guan J, Peixoto GA, Bulut-Karslioglu A, Biechele S, Huang B, Shen X, Ramalho-Santos M. Percharde M, et al. Cell. 2018 Jul 12;174(2):391-405.e19. doi: 10.1016/j.cell.2018.05.043. Epub 2018 Jun 21. Cell. 2018. PMID: 29937225 Free PMC article.

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References

1. Chuong EB, Elde NC, and Feschotte C (2017). Regulatory activities of transposable elements: from conflicts to benefits. Nat. Rev. Genet 18, 71–86. - PMC - PubMed
1. De Iaco A, Planet E, Coluccio A, Verp S, Duc J, and Trono D (2017). DUX-family transcription factors regulate zygotic genome activation in placental mammals. Nat. Genet 49, 941–945. - PMC - PubMed
1. Gabellini D, Green MR, and Tupler R (2002). Inappropriate gene activation in FSHD: a repressor complex binds a chromosomal repeat deleted in dystrophic muscle. Cell 110, 339–348. - PubMed
1. Ginisty H, Amalric F, and Bouvet P (1998). Nucleolin functions in the first step of ribosomal RNA processing. EMBO J 17, 1476–1486. - PMC - PubMed
1. Hendrickson PG, Doráis JA, Grow EJ, Whiddon JL, Lim JW, Wike CL, Weaver BD, Pflueger C, Emery BR, Wilcox AL, et al. (2017). Conserved roles of mouse DUX and human DUX4 in activating cleavage-stage genes and MERVL/HERVL retrotransposons. Nat. Genet 49, 925–934. - PMC - PubMed

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[1] Chuong EB, Elde NC, and Feschotte C (2017). Regulatory activities of transposable elements: from conflicts to benefits. Nat. Rev. Genet 18, 71–86. - PMC - PubMed

[2] Chuong EB, Elde NC, and Feschotte C (2017). Regulatory activities of transposable elements: from conflicts to benefits. Nat. Rev. Genet 18, 71–86. - PMC - PubMed

[3] De Iaco A, Planet E, Coluccio A, Verp S, Duc J, and Trono D (2017). DUX-family transcription factors regulate zygotic genome activation in placental mammals. Nat. Genet 49, 941–945. - PMC - PubMed

[4] De Iaco A, Planet E, Coluccio A, Verp S, Duc J, and Trono D (2017). DUX-family transcription factors regulate zygotic genome activation in placental mammals. Nat. Genet 49, 941–945. - PMC - PubMed

[5] Gabellini D, Green MR, and Tupler R (2002). Inappropriate gene activation in FSHD: a repressor complex binds a chromosomal repeat deleted in dystrophic muscle. Cell 110, 339–348. - PubMed

[6] Gabellini D, Green MR, and Tupler R (2002). Inappropriate gene activation in FSHD: a repressor complex binds a chromosomal repeat deleted in dystrophic muscle. Cell 110, 339–348. - PubMed

[7] Ginisty H, Amalric F, and Bouvet P (1998). Nucleolin functions in the first step of ribosomal RNA processing. EMBO J 17, 1476–1486. - PMC - PubMed

[8] Ginisty H, Amalric F, and Bouvet P (1998). Nucleolin functions in the first step of ribosomal RNA processing. EMBO J 17, 1476–1486. - PMC - PubMed

[9] Hendrickson PG, Doráis JA, Grow EJ, Whiddon JL, Lim JW, Wike CL, Weaver BD, Pflueger C, Emery BR, Wilcox AL, et al. (2017). Conserved roles of mouse DUX and human DUX4 in activating cleavage-stage genes and MERVL/HERVL retrotransposons. Nat. Genet 49, 925–934. - PMC - PubMed

[10] Hendrickson PG, Doráis JA, Grow EJ, Whiddon JL, Lim JW, Wike CL, Weaver BD, Pflueger C, Emery BR, Wilcox AL, et al. (2017). Conserved roles of mouse DUX and human DUX4 in activating cleavage-stage genes and MERVL/HERVL retrotransposons. Nat. Genet 49, 925–934. - PMC - PubMed

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A lncRNA-like Role for LINE1s in Development

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A lncRNA-like Role for LINE1s in Development

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