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Case Reports
. 2018 Aug;24(8):1524-1527.
doi: 10.3201/eid2408.171865.

Hospitalized Patient as Source of Aspergillus fumigatus, 2015

Baptiste Lemaire, Anne-Cécile Normand, Jean-Marie Forel, Nadim Cassir, Renaud Piarroux, Stéphane Ranque
Case Reports

Hospitalized Patient as Source of Aspergillus fumigatus, 2015

Baptiste Lemaire et al. Emerg Infect Dis. 2018 Aug.

Abstract

Hospital-acquired aspergillosis is usually associated with environmental contamination. In 2015, continuous monitoring of airborne fungi and multilocus variable-number tandem-repeat analysis identified the source of Aspergillus fumigatus as the airway of a patient. Therefore, patients colonized with Aspergillus spp. should be treated in airborne infection isolation rooms.

Keywords: Aspergillus fumigatus; France; airborne contamination; aspergillosis; fungi; hospital infections; intensive care units.

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Figures

Figure 1
Figure 1
Timeline summarizing the antifungal treatments, patient blood and respiratory sample mycology culture results, and filamentous fungi culture results of the electrostatic dustfall collectors used for continuous monitoring of airborne fungal contamination in the intensive care unit rooms where Aspergillus fumigatus was found during hospital stay of colonized patient, France, 2015. C. albicans, Candida albicans.
Figure 2
Figure 2
Multilocus variable-number tandem-repeat analysis genotyping results for Aspergillus fumigatus found during hospital stay of colonized patient, France, 2015. The distance tree was plotted by using iTOL version 4.2 (https://itol.embl.de/), taking into account the 3 microsatellite markers that were obtained from each A. fumigatus isolate sampled from the various study sites. The length-polymorphisms of 9 microsatellite markers were obtained for the 14 isolates sampled at the ICU during the patient’s stay and 1 control. ICU room locations are detailed in the Technical Appendix. CF, cystic fibrosis center; EDC, electrostatic dustfall collector; EXT, a school in northeastern France; ICU, intensive care unit; MRS, Marseille; PFT, pulmonary function testing center; PICU, pediatric intensive care unit. Scale bar indicates nucleotide substitutions per site.
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