Cell Signaling in Neuronal Stem Cells

doi:10.3390/cells7070075

Review

. 2018 Jul 14;7(7):75.

doi: 10.3390/cells7070075.

Cell Signaling in Neuronal Stem Cells

Elkin Navarro Quiroz^{1

2}, Roberto Navarro Quiroz³, Mostapha Ahmad⁴, Lorena Gomez Escorcia⁵, Jose Luis Villarreal⁶, Cecilia Fernandez Ponce⁷, Gustavo Aroca Martinez^{8

9}

Affiliations

¹ Faculty of basic sciences and biomedical; Universidad Simón Bolívar, Barranquilla 080002, Colombia. enavarro26@unisimonbolivar.edu.co.
² School of Medicine, Universidad Rafael Nuñez, Cartagena 130001, Colombia. enavarro26@unisimonbolivar.edu.co.
³ Centro de Investigación en Salud para el Trópico, Universidad Cooperativa de Colombia, Santa Marta 470002, Colombia. robertcnavarro@gmail.com.
⁴ Faculty of basic sciences and biomedical; Universidad Simón Bolívar, Barranquilla 080002, Colombia. mostapha.ahmad@unisimonbolivar.edu.co.
⁵ Faculty of basic sciences and biomedical; Universidad Simón Bolívar, Barranquilla 080002, Colombia. lorenagomez1212@gmail.com.
⁶ School of Medicine, Universidad Libre, Barranquilla 080002, Colombia. josevillarrealc@gmail.com.
⁷ School of Medicine, Universidad de Cadiz, Cadiz 110003, Spain. cecimat20@yahoo.com.
⁸ Faculty of basic sciences and biomedical; Universidad Simón Bolívar, Barranquilla 080002, Colombia. garoca1@unisimonbolivar.edu.co.
⁹ Clinica de la Costa, Barranquilla 080002, Colombia. garoca1@unisimonbolivar.edu.co.

PMID: 30011912
PMCID: PMC6070865
DOI: 10.3390/cells7070075

Review

Cell Signaling in Neuronal Stem Cells

Elkin Navarro Quiroz et al. Cells. 2018.

. 2018 Jul 14;7(7):75.

doi: 10.3390/cells7070075.

Authors

Elkin Navarro Quiroz^{1

2}, Roberto Navarro Quiroz³, Mostapha Ahmad⁴, Lorena Gomez Escorcia⁵, Jose Luis Villarreal⁶, Cecilia Fernandez Ponce⁷, Gustavo Aroca Martinez^{8

9}

Affiliations

¹ Faculty of basic sciences and biomedical; Universidad Simón Bolívar, Barranquilla 080002, Colombia. enavarro26@unisimonbolivar.edu.co.
² School of Medicine, Universidad Rafael Nuñez, Cartagena 130001, Colombia. enavarro26@unisimonbolivar.edu.co.
³ Centro de Investigación en Salud para el Trópico, Universidad Cooperativa de Colombia, Santa Marta 470002, Colombia. robertcnavarro@gmail.com.
⁴ Faculty of basic sciences and biomedical; Universidad Simón Bolívar, Barranquilla 080002, Colombia. mostapha.ahmad@unisimonbolivar.edu.co.
⁵ Faculty of basic sciences and biomedical; Universidad Simón Bolívar, Barranquilla 080002, Colombia. lorenagomez1212@gmail.com.
⁶ School of Medicine, Universidad Libre, Barranquilla 080002, Colombia. josevillarrealc@gmail.com.
⁷ School of Medicine, Universidad de Cadiz, Cadiz 110003, Spain. cecimat20@yahoo.com.
⁸ Faculty of basic sciences and biomedical; Universidad Simón Bolívar, Barranquilla 080002, Colombia. garoca1@unisimonbolivar.edu.co.
⁹ Clinica de la Costa, Barranquilla 080002, Colombia. garoca1@unisimonbolivar.edu.co.

PMID: 30011912
PMCID: PMC6070865
DOI: 10.3390/cells7070075

Abstract

The defining characteristic of neural stem cells (NSCs) is their ability to multiply through symmetric divisions and proliferation, and differentiation by asymmetric divisions, thus giving rise to different types of cells of the central nervous system (CNS). A strict temporal space control of the NSC differentiation is necessary, because its alterations are associated with neurological dysfunctions and, in some cases, death. This work reviews the current state of the molecular mechanisms that regulate the transcription in NSCs, organized according to whether the origin of the stimulus that triggers the molecular cascade in the CNS is internal (intrinsic factors) or whether it is the result of the microenvironment that surrounds the CNS (extrinsic factors).

Keywords: Wnt/beta-Catenin; differentiation; neural stem cell.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

**Figure 1**
Molecular mechanism that regulates the differentiation of neuronal stem cells.

See this image and copyright information in PMC

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References

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[1] Rosow K., Holzapfel A., Karlawish J.H., Baumgart M., Bain L.J., Khachaturian A.S. Countrywide strategic plans on Alzheimer’s disease: Developing the framework for the international battle against Alzheimer’s disease. Alzheimer’s Dement. 2011;7:615–621. doi: 10.1016/j.jalz.2011.09.226. - DOI - PubMed

[2] Rosow K., Holzapfel A., Karlawish J.H., Baumgart M., Bain L.J., Khachaturian A.S. Countrywide strategic plans on Alzheimer’s disease: Developing the framework for the international battle against Alzheimer’s disease. Alzheimer’s Dement. 2011;7:615–621. doi: 10.1016/j.jalz.2011.09.226. - DOI - PubMed

[3] Chae T.H., Kim S., Marz K.E., Hanson P.I., Walsh C.A. The hyh mutation uncovers roles for αSnap in apical protein localization and control of neural cell fate. Nat. Genet. 2004;36:264–270. doi: 10.1038/ng1302. - DOI - PubMed

[4] Chae T.H., Kim S., Marz K.E., Hanson P.I., Walsh C.A. The hyh mutation uncovers roles for αSnap in apical protein localization and control of neural cell fate. Nat. Genet. 2004;36:264–270. doi: 10.1038/ng1302. - DOI - PubMed

[5] Gage F.H. Mammalian neural stem cells. Science. 2000;287:1433–1438. doi: 10.1126/science.287.5457.1433. - DOI - PubMed

[6] Gage F.H. Mammalian neural stem cells. Science. 2000;287:1433–1438. doi: 10.1126/science.287.5457.1433. - DOI - PubMed

[7] Shi Y., Sun G., Zhao C., Stewart R. Neural stem cell self-renewal. Crit. Rev. Oncol. Hematol. 2008;65:43–53. doi: 10.1016/j.critrevonc.2007.06.004. - DOI - PMC - PubMed

[8] Shi Y., Sun G., Zhao C., Stewart R. Neural stem cell self-renewal. Crit. Rev. Oncol. Hematol. 2008;65:43–53. doi: 10.1016/j.critrevonc.2007.06.004. - DOI - PMC - PubMed

[9] Shi Y., Chichung Lie D., Taupin P., Nakashima K., Ray J., Yu R.T., Gage F.H., Evans R.M. Expression and function of orphan nuclear receptor TLX in adult neural stem cells. Nature. 2004;427:78–83. doi: 10.1038/nature02211. - DOI - PubMed

[10] Shi Y., Chichung Lie D., Taupin P., Nakashima K., Ray J., Yu R.T., Gage F.H., Evans R.M. Expression and function of orphan nuclear receptor TLX in adult neural stem cells. Nature. 2004;427:78–83. doi: 10.1038/nature02211. - DOI - PubMed

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Cell Signaling in Neuronal Stem Cells

Affiliations

Cell Signaling in Neuronal Stem Cells

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Affiliations

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Conflict of interest statement

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