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Review
. 2019 Apr;68(4):645-660.
doi: 10.1007/s00262-018-2200-6. Epub 2018 Jul 12.

Interactions among myeloid regulatory cells in cancer

Viktor Umansky  1   2 , Gosse J Adema  3 , Jaroslaw Baran  4 , Sven Brandau  5 , Jo A Van Ginderachter  6   7 , Xiaoying Hu  8   9 , Jadwiga Jablonska  5 , Slavko Mojsilovic  10 , Helen A Papadaki  11 , Yago Pico de Coaña  12 , Kim C M Santegoets  3 , Juan F Santibanez  13   14 , Karine Serre  15 , Yu Si  5 , Isabela Sieminska  4 , Maria Velegraki  11 , Zvi G Fridlender  16
Affiliations
Review

Interactions among myeloid regulatory cells in cancer

Viktor Umansky et al. Cancer Immunol Immunother. 2019 Apr.

Abstract

Mounting evidence has accumulated on the critical role of the different myeloid cells in the regulation of the cancerous process, and in particular in the modulation of the immune reaction to cancer. Myeloid cells are a major component of host cells infiltrating tumors, interacting with each other, with tumor cells and other stromal cells, and demonstrating a prominent plasticity. We describe here various myeloid regulatory cells (MRCs) in mice and human as well as their relevant therapeutic targets. We first address the role of the monocytes and macrophages that can contribute to angiogenesis, immunosuppression and metastatic dissemination. Next, we discuss the differential role of neutrophil subsets in tumor development, enhancing the dual and sometimes contradicting role of these cells. A heterogeneous population of immature myeloid cells, MDSCs, was shown to be generated and accumulated during tumor progression as well as to be an important player in cancer-related immune suppression. Lastly, we discuss the role of myeloid DCs, which can either contribute to effective anti-tumor responses or play a more regulatory role. We believe that MRCs play a critical role in cancer-related immune regulation and suggest that future anti-cancer therapies will focus on these abundant cells.

Keywords: Dendritic cells; Macrophages; Mye-EUNITER; Myeloid regulatory cells; Myeloid-derived suppressor cells; Neutrophils.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1
Fig. 1
Multiple effects and interactions among the different types of MRCs in cancer. Mϕ Macrophages, M2 M2 macrophages, TAN tumor-associated neutrophils, N2 N2 TAN, Mo-MDSC monocytic myeloid-derived suppressor cells, PMN-MDSC polymorphonuclear MDSC, DC dendritic cells, Treg regulatory T cells
Fig. 2
Fig. 2
Effects of tumor cells on MRC subsets and that of MRCs on T cell subpopulations in cancer. M2 M2 macrophages, N2 N2 tumor-associated neutrophils, Mo-MDSC monocytic myeloid-derived suppressor cells, PMN-MDSC polymorphonuclear MDSC, DC dendritic cells, Treg regulatory T cells
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