Comparative Study
doi: 10.1021/jm00149a011.
Angiotensin converting enzyme inhibitors: N-substituted D-glutamic acid gamma dipeptides
- PMID: 2999395
- DOI: 10.1021/jm00149a011
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Comparative Study
Angiotensin converting enzyme inhibitors: N-substituted D-glutamic acid gamma dipeptides
J Med Chem.
1985 Nov.
Abstract
The preparation of two series of N-carbobenzoxy-gamma-D-glutamyl secondary 2S amino acids and (N-substituted gamma-D-glutamyl)indoline-2(S)-carboxylic acid dipeptides is described. In vitro inhibition of angiotensin converting enzyme (ACE) is reported for each compound, and the structure-activity relationship is discussed. Oral and iv inhibition of AI pressor response in vivo of selected compounds in Table II is also discussed. The most potent compounds in vitro, 3 and 6a, had an ACE IC50 of 7 and 2.7 X 10(-9) M, respectively.
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