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Comparative Study
. 1985 Jul 30;144(2):457-67.
doi: 10.1016/0042-6822(85)90286-7.

Nucleotide sequence of the envelope gene of radiation leukemia virus

J Merregaert, J M Nuyten, M Janowski
Comparative Study

Nucleotide sequence of the envelope gene of radiation leukemia virus

J Merregaert et al. Virology. .

Abstract

The nucleotide sequence and the predicted amino acid sequence of the envelope gene (env) of RadLV/VL3 (T+L+) has been determined. RadLV/VL3 (T+L+) is a highly thymotropic (T+) and leukemogenic (L+) murine recombinant retrovirus continuously produced at high titer by BL/VL3 cells, a line established in culture from a radiation leukemia virus (RadLV)-induced C57BL/Ka mouse thymic lymphoma. The envelope gene is strikingly similar (92% homologous) to that encoded by the ecotropic Akv-MuLV. Among the differences, 134 scattered, although unevenly distributed point mutations (6.4%), two 9-bp deletions as well as a 6-bp insertion were observed (which result in 49 amino acid changes in the env gene of RadLV/VL3 (T+L+)).

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