A Brief Overview of Progranulin in Health and Disease

doi:10.1007/978-1-4939-8559-3_1

Review

. 2018:1806:3-15.

doi: 10.1007/978-1-4939-8559-3_1.

A Brief Overview of Progranulin in Health and Disease

Andrew Bateman^{1

2}, Siu Tim Cheung^{3

4}, Hugh P J Bennett^{5

6}

Affiliations

¹ Department of Medicine, McGill University, Montreal, QC, Canada. andrew.bateman@mcgill.ca.
² Program in Metabolic Diseases and Their Complications, Centre for Translational Biology, Research Institute of McGill University Health Centre, Montreal, QC, Canada. andrew.bateman@mcgill.ca.
³ Department of Surgery, The Chinese University of Hong Kong, Hong Kong, China.
⁴ Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China.
⁵ Department of Medicine, McGill University, Montreal, QC, Canada.
⁶ Program in Metabolic Diseases and Their Complications, Centre for Translational Biology, Research Institute of McGill University Health Centre, Montreal, QC, Canada.

PMID: 29956265
DOI: 10.1007/978-1-4939-8559-3_1

Review

A Brief Overview of Progranulin in Health and Disease

Andrew Bateman et al. Methods Mol Biol. 2018.

. 2018:1806:3-15.

doi: 10.1007/978-1-4939-8559-3_1.

Authors

Andrew Bateman^{1

2}, Siu Tim Cheung^{3

4}, Hugh P J Bennett^{5

6}

Affiliations

¹ Department of Medicine, McGill University, Montreal, QC, Canada. andrew.bateman@mcgill.ca.
² Program in Metabolic Diseases and Their Complications, Centre for Translational Biology, Research Institute of McGill University Health Centre, Montreal, QC, Canada. andrew.bateman@mcgill.ca.
³ Department of Surgery, The Chinese University of Hong Kong, Hong Kong, China.
⁴ Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China.
⁵ Department of Medicine, McGill University, Montreal, QC, Canada.
⁶ Program in Metabolic Diseases and Their Complications, Centre for Translational Biology, Research Institute of McGill University Health Centre, Montreal, QC, Canada.

PMID: 29956265
DOI: 10.1007/978-1-4939-8559-3_1

Abstract

The purpose of this brief overview of the progranulin protein is to provide a sense of the range and extent of the roles of progranulin in normal physiology and pathology. Progranulin has received attention due to its role in neurodegeneration, where mutation of a single copy of GRN, the gene encoding progranulin, results in frontotemporal dementia, whereas viral delivery of progranulin to the brains of mice exhibiting Parkinson's or Alzheimer's disease phenotypes inhibits the progression of the neurodegenerative phenotypes. Of equal importance, progranulin protects tissues against the harmful effects of poorly controlled inflammation and promotes tissue regeneration after injury at a multitude of sites throughout the body. Progranulin is overexpressed by many types of cancer and contributes to their progression. Given suitable analytical methods and model systems, progranulin offers a wealth of research possibilities.

Keywords: Acrogranin; Cancer; Development; Epithelial transforming growth factor (TGFe); Epithelin; Granulin; Granulin-epithelin precursor; Inflammation; Neurodegeneration; PC-cell-derived growth factor; Proepithelin; Progranulin; Repair; Wounds.

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A Brief Overview of Progranulin in Health and Disease

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A Brief Overview of Progranulin in Health and Disease

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