Tissue-Specific Control of Tissue-Resident Memory T Cells

doi:10.1615/CritRevImmunol.2018025653

Review

. 2018;38(2):79-103.

doi: 10.1615/CritRevImmunol.2018025653.

Tissue-Specific Control of Tissue-Resident Memory T Cells

Yong Liu¹, Chaoyu Ma², Nu Zhang³

Affiliations

¹ Department of Microbiology, Immunology and Molecular Genetics, School of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229; Department of Otolaryngology Head and Neck Surgery, Xiangya Hospital, Central South Univeristy, Changsha, Hunan 410008, China.
² Department of Microbiology, Immunology and Molecular Genetics, School of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229.
³ Department of Microbiology, Immunology and Molecular Genetics, School of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229; The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China.

PMID: 29953389
PMCID: PMC6156774
DOI: 10.1615/CritRevImmunol.2018025653

Review

Tissue-Specific Control of Tissue-Resident Memory T Cells

Yong Liu et al. Crit Rev Immunol. 2018.

. 2018;38(2):79-103.

doi: 10.1615/CritRevImmunol.2018025653.

Authors

Yong Liu¹, Chaoyu Ma², Nu Zhang³

Affiliations

¹ Department of Microbiology, Immunology and Molecular Genetics, School of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229; Department of Otolaryngology Head and Neck Surgery, Xiangya Hospital, Central South Univeristy, Changsha, Hunan 410008, China.
² Department of Microbiology, Immunology and Molecular Genetics, School of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229.
³ Department of Microbiology, Immunology and Molecular Genetics, School of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229; The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China.

PMID: 29953389
PMCID: PMC6156774
DOI: 10.1615/CritRevImmunol.2018025653

Abstract

Tissue-resident memory T (TRM) cells have emerged as a major component of T cell biology. Recent investigations have greatly advanced our understanding of TRMs. Common features have been discovered to distinguish memory T cells residing in various mucosal and non-mucosal tissues from their circulating counterparts. Given that most organs and tissues contain a unique microenvironment, local signal-induced tissue-specific features are tightly associated with the differentiation, homeostasis, and protective functions of TRMs. Here, we discuss recent advances in the TRM field with a special emphasis on the interaction between local signals and TRMs in the context of individual tissue environment.

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Conflict of interest statement

Conflict of Interest

The authors declare no competing financial interests.

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References

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[1] Jenkins MK, Chu HH, McLachlan JB & Moon JJ On the composition of the preimmune repertoire of T cells specific for Peptide-major histocompatibility complex ligands. Annu Rev Immunol 28, 275–294, doi:10.1146/annurev-immunol-030409-101253 (2010). - DOI - PubMed

[2] Jenkins MK, Chu HH, McLachlan JB & Moon JJ On the composition of the preimmune repertoire of T cells specific for Peptide-major histocompatibility complex ligands. Annu Rev Immunol 28, 275–294, doi:10.1146/annurev-immunol-030409-101253 (2010). - DOI - PubMed

[3] Mackay CR, Marston WL & Dudler L Naive and memory T cells show distinct pathways of lymphocyte recirculation. J Exp Med 171, 801–817 (1990). - PMC - PubMed

[4] Mackay CR, Marston WL & Dudler L Naive and memory T cells show distinct pathways of lymphocyte recirculation. J Exp Med 171, 801–817 (1990). - PMC - PubMed

[5] Zhang N & Bevan MJ CD8(+) T cells: foot soldiers of the immune system. Immunity 35, 161–168, doi:10.1016/j.immuni.2011.07.010 (2011). - DOI - PMC - PubMed

[6] Zhang N & Bevan MJ CD8(+) T cells: foot soldiers of the immune system. Immunity 35, 161–168, doi:10.1016/j.immuni.2011.07.010 (2011). - DOI - PMC - PubMed

[7] Williams MA & Bevan MJ Effector and memory CTL differentiation. Annu Rev Immunol 25, 171–192, doi:10.1146/annurev.immunol.25.022106.141548 (2007). - DOI - PubMed

[8] Williams MA & Bevan MJ Effector and memory CTL differentiation. Annu Rev Immunol 25, 171–192, doi:10.1146/annurev.immunol.25.022106.141548 (2007). - DOI - PubMed

[9] Ahmed R, Bevan MJ, Reiner SL & Fearon DT The precursors of memory: models and controversies. Nat Rev Immunol 9, 662–668, doi:10.1038/nri2619 (2009). - DOI - PubMed

[10] Ahmed R, Bevan MJ, Reiner SL & Fearon DT The precursors of memory: models and controversies. Nat Rev Immunol 9, 662–668, doi:10.1038/nri2619 (2009). - DOI - PubMed

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Tissue-Specific Control of Tissue-Resident Memory T Cells

Affiliations

Tissue-Specific Control of Tissue-Resident Memory T Cells

Authors

Affiliations

Abstract

Conflict of interest statement

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References

Publication types

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Grants and funding

LinkOut - more resources

Full Text Sources

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