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Review
. 2018;12(4):386-393.
doi: 10.1080/19336918.2018.1485618. Epub 2018 Aug 1.

DDR1 and DDR2 in skin

Muriel Cario  1
Affiliations
Review

DDR1 and DDR2 in skin

Muriel Cario. Cell Adh Migr. 2018.

Abstract

DDR1 and DDR2 are expressed in skin but their expression differs according to the skin compartment, epidermis, dermis, hypodermis and to the embryonic origin of the cells. In skin, it seems that during physiological processes such as wound healing or pathological processes such as tumorigenesis or systemic sclerosis development only one of the DDR is dysregulated. Furthermore, the altered DDR in pathological process is not necessarily the DDR implicated in basal homeostasis. Indeed, in epidermis, while DDR1 is the main DDR involved in melanocyte homeostasis, DDR2 seems to be the main DDR implicated in melanoma. On the contrary, in dermis, while DDR2 is necessary for normal wound healing, dysregulation of DDR1 is associated with abnormal wound healing leading to keloid. In conclusion, targeting DDR could be a therapeutic solution, however side effects have to be managed carefully.

Keywords: CCN3; Melanocyte; cadherin; cell adhesive proteins; fibroblast; integrins; keratinocyte.

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Figures

Figure 1.
Figure 1.
Morphology of adult human skin. Staining on human mammary skin from 45-year-old phototype III female. Fontana-Masson staining revealing melanin in dark and hematoxylin counterstaining revealing nucleus in blue.
Figure 2.
Figure 2.
(a) Expression of DDR1 in human adult skin. Immunohistochemistry performed on mammary skin from 35-year-old phototype II female. Anti-DDR1 (abcam ab37838) detected using HRP-Envision+ system (Dako) followed by incubation with VIP (vector laboratory). DDR1 appears in violet-brown. Hematoxylin counterstaining reveals nucleus in blue. (b) Schematic representation of DDR1 localization in melanocyte.
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