Review
doi: 10.1016/j.tcb.2018.06.002.
Epub 2018 Jun 23.
Illuminating GPCR Signaling by Cryo-EM
Affiliations
- PMID: 29945844
- DOI: 10.1016/j.tcb.2018.06.002
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Review
Illuminating GPCR Signaling by Cryo-EM
Trends Cell Biol.
2018 Aug.
Abstract
The wave of resolution revolution in cryo-EM has touched, and made a significant impact on, the structural biology of GPCRs. High-resolution structures of several GPCR-G-protein complexes are now determined by cryo-EM and they illuminate fine structural details of this central macromolecular complex involved in cellular signaling.
Keywords: GPCR; arrestins; biased signaling; cryo-EM; negative-staining.
Copyright © 2018 Elsevier Ltd. All rights reserved.
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