doi: 10.1021/acs.jnatprod.8b00417.
Epub 2018 Jun 26.
Izenamides A and B, Statine-Containing Depsipeptides, and an Analogue from a Marine Cyanobacterium
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- PMID: 29944370
- DOI: 10.1021/acs.jnatprod.8b00417
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Izenamides A and B, Statine-Containing Depsipeptides, and an Analogue from a Marine Cyanobacterium
J Nat Prod.
.
Abstract
Izenamides A, B, and C (1-3), new linear depsipeptides, were isolated from a taxonomically distinct marine cyanobacterium. Izenamides A and B contain a statine moiety [(3 S,4 S)-4-amino-3-hydroxy-6-methylheptanoic acid] and inhibited the activity of cathepsin D, an aspartic peptidase. Meanwhile, izenamides did not show growth-inhibitory activity against HeLa, HL60, or MCF-7 cells at up to 10 μM.
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