Evaluation of trace metals in follicular fluid in ICSI-treated patients
- PMID: 29936824
- DOI: 10.26444/aaem/75422
Evaluation of trace metals in follicular fluid in ICSI-treated patients
Abstract
This study investigated the influence of cadmium (Cd), copper (Cu), iron (Fe), lead (Pb), selenium (Se), and zinc (Zn) in follicular fluid on the effectiveness of in vitro fertilization (IVF) treatment and the dynamics of embryo development. The study involved 221 women aged 25-35 years in whom intracytoplasmic sperm injection (ICSI) was performed. Analysis of the effects of the average concentrations of Se, Zn, and Cu on the evelopmental dynamics of embryos showed that higher concentrations of these metals were accompanied by shorter lead times for each of the various stages of development, while the reverse was true in the case of cadmium and lead. No relationship was observed between the mean concentrations of Fe and the dynamics of the human embryo. In order to discover whether the fact of becoming pregnant is affected by the investigated variables, a logistic regression model was applied. The dependent variable was the fact of achieving pregnancy, and the independent variable tested was the level of trace metals. Ultimately, only one variable remained statistically significant in the model: the level of Se.
Keywords: embryo development dynamics; follicular fluid; intracytoplasmic sperm injection (ICSI); time-lapse monitoring; trace metals.
Similar articles
-
[Detection of cadmium and zinc in the blood and follicular fluid in women in the IVF and ET program].Ceska Gynekol. 1998 Aug;63(4):292-300. Ceska Gynekol. 1998. PMID: 9750404 Czech.
-
Associations of toxic and essential trace elements in serum, follicular fluid, and seminal plasma with In vitro fertilization outcomes.Ecotoxicol Environ Saf. 2020 Nov;204:110965. doi: 10.1016/j.ecoenv.2020.110965. Epub 2020 Aug 13. Ecotoxicol Environ Saf. 2020. PMID: 32798747
-
Heavy metal and trace element concentrations in blood and follicular fluid affect ART outcome.Eur J Obstet Gynecol Reprod Biol. 2016 Mar;198:73-77. doi: 10.1016/j.ejogrb.2016.01.001. Epub 2016 Jan 11. Eur J Obstet Gynecol Reprod Biol. 2016. PMID: 26802253
-
[Bioavailability from foods of trace elements: iron, zinc, copper, selenium, chromium, lead, cadmium, mercury].Ann Ist Super Sanita. 1984;20(2-3):149-69. Ann Ist Super Sanita. 1984. PMID: 6400186 Review. Italian. No abstract available.
-
Good fertilization results associated with high IL-1beta concentrations in follicular fluid of IVF patients.J Reprod Med. 2013 Nov-Dec;58(11-12):485-90. J Reprod Med. 2013. PMID: 24568042
Cited by
-
The Role of One-Carbon Metabolism and Methyl Donors in Medically Assisted Reproduction: A Narrative Review of the Literature.Int J Mol Sci. 2024 May 2;25(9):4977. doi: 10.3390/ijms25094977. Int J Mol Sci. 2024. PMID: 38732193 Free PMC article. Review.
-
Protective effect of resveratrol against cadmium-induced toxicity on ovine oocyte in vitro maturation and fertilization.J Anim Sci Biotechnol. 2022 Jul 22;13(1):83. doi: 10.1186/s40104-022-00731-1. J Anim Sci Biotechnol. 2022. PMID: 35864507 Free PMC article.
-
Cumulus Cell Transcriptome after Cumulus-Oocyte Complex Exposure to Nanomolar Cadmium in an In Vitro Animal Model of Prepubertal and Adult Age.Biology (Basel). 2023 Feb 4;12(2):249. doi: 10.3390/biology12020249. Biology (Basel). 2023. PMID: 36829526 Free PMC article.
-
Ultra-trace element analysis of human follicular fluid by ICP-MS/MS: pre-analytical challenges, contamination control, and matrix effects.J Anal At Spectrom. 2019 Apr 1;34(4):741-752. doi: 10.1039/C8JA00423D. Epub 2019 Feb 25. J Anal At Spectrom. 2019. PMID: 31036984 Free PMC article.
-
Toxic elements in follicular fluid adversely influence the likelihood of pregnancy and live birth in women undergoing IVF.Hum Reprod Open. 2021 Jul 29;2021(3):hoab023. doi: 10.1093/hropen/hoab023. eCollection 2021. Hum Reprod Open. 2021. PMID: 34337160 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
