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. 2018 Aug;45(4):657-662.
doi: 10.1007/s11033-018-4207-7. Epub 2018 Jun 19.

Correlations between gene expression highlight a different activation of ACE/TLR4/PTGS2 signaling in symptomatic and asymptomatic plaques in atherosclerotic patients

Silvia Ferronato  1 , Alberto Scuro  2 , Macarena Gomez-Lira  3 , Sara Mazzucco  4 , Silvia Olivato  4 , Alberto Turco  1 , Orlandi Elisa  1 , Giovanni Malerba  1 , Maria Grazia Romanelli  1
Affiliations

Correlations between gene expression highlight a different activation of ACE/TLR4/PTGS2 signaling in symptomatic and asymptomatic plaques in atherosclerotic patients

Silvia Ferronato et al. Mol Biol Rep. 2018 Aug.

Abstract

Inflammation has a key role and translates the effects of many known risk factors for the disease in atherosclerotic vulnerable plaques. Aiming to look into the elements that induce the development of either a vulnerable or stable atherosclerotic plaque, and considering that inflammation has a central role in the progression of lesions, we analyzed the expression of genes involved in the ACE/TLR4/PTGS2 signaling in carotid plaques of symptomatic and asymptomatic patients. Patients with internal carotid artery stenosis undergoing carotid endarterectomy at Verona University Hospital were included in this study. A total of 71 patients was considered for gene expression analysis (29 atherothrombotic stroke patients and 42 asymptomatic patients). Total RNA was extracted from the excised plaques and expression of PTGS2, ACE, TLR4, PTGER4, PTGER3, EPRAP and ACSL4 genes was analyzed by real-time PCR. The correlation between the pair of genes was studied by Spearman coefficient. From the analyzed genes, we did not observe any individual difference in gene expression but the network of co-expressed genes suggests a different activation of pathways in the two groups of plaques.

Keywords: Atherosclerosis; Gene correlations; Gene expression; Plaque instability.

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