Thymidine Kinase PET Reporter Gene Imaging of Cancer Cells In Vivo
- PMID: 29858789
- DOI: 10.1007/978-1-4939-7860-1_11
Thymidine Kinase PET Reporter Gene Imaging of Cancer Cells In Vivo
Abstract
Positron emission tomography (PET) is a three dimensional imaging modality that detects the accumulation of radiolabeled isotopes in vivo. Ectopic expression of a thymidine kinase reporter gene allows for the specific detection of reporter cells in vivo by imaging with the reporter specific probe. PET reporter imaging is sensitive, quantitative and can be scaled into larger tumors or animals with little to no tissue diffraction. Here, we describe how thymidine kinase PET reporter genes can be used to noninvasively image cancer cells in vivo.
Keywords: HSV-TK; Herpes Simplex Virus Thymidine Kinase; Noninvasive imaging; Positron emission tomography; Reporter gene; Small animal imaging; Thymidine kinase; [18F]-FHBG; sr39TK.
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