Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2018 Nov;233(11):8477-8481.
doi: 10.1002/jcp.26829. Epub 2018 Jun 1.

ARHGAP21 as a master regulator of multiple cellular processes

Lucas R O Rosa  1 , Gabriela M Soares  1 , Leonardo R Silveira  1 , Antonio C Boschero  1 , Helena C L Barbosa-Sampaio  1
Affiliations
Review

ARHGAP21 as a master regulator of multiple cellular processes

Lucas R O Rosa et al. J Cell Physiol. 2018 Nov.

Abstract

The cellular cytoskeleton is involved with multiple biological processes and is tightly regulated by multiple proteins and effectors. Among these, the RhoGTPases family is one of the most important players. RhoGTPAses are, in turn, regulated by many other elements. In the past decade, one of those regulators, the RhoGAP Rho GTPase Activating Protein 21 (ARHGAP21), has been overlooked, despite being implied as having an important role on many of those processes. In this paper, we aimed to review the available literature regarding ARHGAP21 to highlight its importance and the mechanisms of action that have been found so far for this still unknown protein involved with cell adhesion, migration, Golgi regulation, cell trafficking, and even insulin secretion.

Keywords: ARHGAP21; cell dynamics; cytoskeleton; membrane trafficking.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

Publication types

MeSH terms

Substances

LinkOut - more resources