Prospects of IL-2 in Cancer Immunotherapy

doi:10.1155/2018/9056173

Review

. 2018 May 6:2018:9056173.

doi: 10.1155/2018/9056173. eCollection 2018.

Prospects of IL-2 in Cancer Immunotherapy

Affiliations

¹ Department of Biochemistry, Cancer Metabolism and Epigenetic Unit, Faculty of Science, Cancer and Mutagenesis Unit, King Fahd Center for Medical Research, King Abdulaziz University, Jeddah, Saudi Arabia.
² Department of Medicine, University of California, San Francisco, CA 94143, USA.
³ King Fahd Medical Research, King Abdulaziz University, Jeddah, Saudi Arabia.
⁴ Department of Molecular Genetics and Enzymology, Division of Human Genetics and Genome Research, National Research Center, Giza, Egypt.
⁵ Department of Biochemistry, University of Jeddah, Jeddah, Saudi Arabia.
⁶ Center of Excellence in Genomic Medicine Research, King Abdulaziz University, Jeddah, Saudi Arabia.

PMID: 29854806
PMCID: PMC5960517
DOI: 10.1155/2018/9056173

Review

Prospects of IL-2 in Cancer Immunotherapy

Hani Choudhry et al. Biomed Res Int. 2018.

. 2018 May 6:2018:9056173.

doi: 10.1155/2018/9056173. eCollection 2018.

Authors

Affiliations

¹ Department of Biochemistry, Cancer Metabolism and Epigenetic Unit, Faculty of Science, Cancer and Mutagenesis Unit, King Fahd Center for Medical Research, King Abdulaziz University, Jeddah, Saudi Arabia.
² Department of Medicine, University of California, San Francisco, CA 94143, USA.
³ King Fahd Medical Research, King Abdulaziz University, Jeddah, Saudi Arabia.
⁴ Department of Molecular Genetics and Enzymology, Division of Human Genetics and Genome Research, National Research Center, Giza, Egypt.
⁵ Department of Biochemistry, University of Jeddah, Jeddah, Saudi Arabia.
⁶ Center of Excellence in Genomic Medicine Research, King Abdulaziz University, Jeddah, Saudi Arabia.

PMID: 29854806
PMCID: PMC5960517
DOI: 10.1155/2018/9056173

Abstract

IL-2 is a powerful immune growth factor and it plays important role in sustaining T cell response. The potential of IL-2 in expanding T cells without loss of functionality has led to its early use in cancer immunotherapy. IL-2 has been reported to induce complete and durable regressions in cancer patients but immune related adverse effects have been reported (irAE). The present review discusses the prospects of IL-2 in immunotherapy for cancer.

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Figures

**Figure 1**
Showing three different types of IL-2 receptors.

See this image and copyright information in PMC

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References

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1. Leonard W. J. Cytokines and immunodeficiency diseases. 2001;1(3):200–208. doi: 10.1038/35105066. - DOI - PubMed

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[1] Boyman O., Sprent J. The role of interleukin-2 during homeostasis and activation of the immune system. 2012;12(3):180–190. doi: 10.1038/nri3156. - DOI - PubMed

[2] Boyman O., Sprent J. The role of interleukin-2 during homeostasis and activation of the immune system. 2012;12(3):180–190. doi: 10.1038/nri3156. - DOI - PubMed

[3] Waldmann T., Tagaya Y., Bamford R. Interleukin-2, interleukin-15, and their receptors. 1998;16(3-4):205–226. doi: 10.3109/08830189809042995. - DOI - PubMed

[4] Waldmann T., Tagaya Y., Bamford R. Interleukin-2, interleukin-15, and their receptors. 1998;16(3-4):205–226. doi: 10.3109/08830189809042995. - DOI - PubMed

[5] Taniguchi T., Matsui H., Fujita T., et al. Structure and expression of a cloned cDNA for human interleukin-2. 1983;302(5906):305–310. doi: 10.1038/302305a0. - DOI - PubMed

[6] Taniguchi T., Matsui H., Fujita T., et al. Structure and expression of a cloned cDNA for human interleukin-2. 1983;302(5906):305–310. doi: 10.1038/302305a0. - DOI - PubMed

[7] Nikaido T., Shimizu A., Ishida N., et al. Molecular cloning of cDNA encoding human interleukin-2 receptor. 1984;311(5987):631–635. doi: 10.1038/311631a0. - DOI - PubMed

[8] Nikaido T., Shimizu A., Ishida N., et al. Molecular cloning of cDNA encoding human interleukin-2 receptor. 1984;311(5987):631–635. doi: 10.1038/311631a0. - DOI - PubMed

[9] Leonard W. J. Cytokines and immunodeficiency diseases. 2001;1(3):200–208. doi: 10.1038/35105066. - DOI - PubMed

[10] Leonard W. J. Cytokines and immunodeficiency diseases. 2001;1(3):200–208. doi: 10.1038/35105066. - DOI - PubMed

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Prospects of IL-2 in Cancer Immunotherapy

Affiliations

Prospects of IL-2 in Cancer Immunotherapy

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